Universität zu Köln

Svacina, Martin K. R. and Lehmann, Helmar C. (2022). Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): Current Therapies and Future Approaches. Curr. Pharm. Design, 28 (11). S. 854 - 863. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1873-4286

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated polyradiculoneuropathy leading to disability via inflammatory demyelination of peripheral nerves. Various therapeutic approaches with different mechanisms of action are established for the treatment of CIDP. Of those, corticosteroids, intravenous or subcutaneous immunoglobulin, or plasma exchange are established first-line therapies as suggested by the recently revised EAN/PNS guidelines for the management of CIDP. In special cases, immunosuppressants or rituximab may be used. Novel therapeutic approaches currently undergoing clinical studies include molecules or monoclonal antibodies interacting with Fc receptors on immune cells to alleviate immune-mediated neuronal damage. Despite various established therapies and the current development of novel therapeutics, treatment of CIDP remains challenging due to an heterogeneous disease course and the lack of surrogate parameters to predict the risk of clinical deterioration. This review summarizes established therapies for CIDP and provides an outlook on future therapeutic approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Svacina, Martin K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Helmar C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-663340
DOI:	10.2174/1381612828666220325102840
Journal or Publication Title:	Curr. Pharm. Design
Volume:	28
Number:	11
Page Range:	S. 854 - 863
Date:	2022
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1873-4286
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THERAPEUTIC PLASMA-EXCHANGE; NERVE SOCIETY GUIDELINE; DOUBLE-BLIND; SUBCUTANEOUS IMMUNOGLOBULIN; INTRAVENOUS IMMUNOGLOBULIN; MAINTENANCE TREATMENT; POLYRADICULONEUROPATHY REPORT; NEUROIMMUNOLOGICAL DISORDERS; TRYPTOPHAN IMMUNOADSORPTION; FC Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66334