Human metapneumovirus infection in the cardiac paediatric ICU before and during COVID-19 pandemic: a retrospective cohort analysis

Leister, Nicolas ORCID: 0000-0003-1932-0701, Commotio, Simone, Menzel, Christoph, Yucetepe, Sirin, Ulrichs, Christoph, Wendt, Stefanie, Dedden, Christoph, Trieschmann, Uwe ORCID: 0000-0003-2529-9005 and Hannes, Tobias . Human metapneumovirus infection in the cardiac paediatric ICU before and during COVID-19 pandemic: a retrospective cohort analysis. Cardiol. Young. CAMBRIDGE: CAMBRIDGE UNIV PRESS. ISSN 1467-1107

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DOI:10.1017/S1047951122002645

Abstract

Introduction: This study investigates the hygiene standards in the context of the COVID-19 pandemic and their impact on the perioperative incidence of human metapneumovirus as well as the typical symptom burden of human metapneumovirus-infected children with CHDs. Materials and methods: Between March 2018 and July 2021, all patients of a cardiac paediatric ICU of a German university hospital were included in this retrospective cohort analysis. Results: A total of 589 patients with CHD were included in the analysis. Three hundred and fifty-two patients (148 females and 204 males) were admitted before the introduction of social distancing and face masks between March 2018 and 15 April 2020 (cohort A). Two hundred and thirty-seven patients (118 females and 119 males) were admitted after the introduction between April 16 and July 2021 (cohort B). In cohort A, human metapneumovirus was detected in 11 out of 352 patients (3.1%) during their stay at cardiac paediatric ICU. In cohort B, one patient out of 237 (0.4%) tested positive for human metapneumovirus. Patients who tested positive for human metapneumovirus stayed in cardiac paediatric ICU for a median of 17.5 days (range, 2-45 days). Patients without a detected human metapneumovirus infection stayed in the cardiac paediatric ICU for a median of 4 days (range, 0.5-114 days). Nine out of 12 (75%) human metapneumovirus-positive patients showed atelectasis. Conclusion: Perioperative human metapneumovirus infections prolong cardiac paediatric ICU stay in children with CHD. In affected patients, pulmonary impairment with typical symptoms appears. Under certain circumstances, a complication-rich perioperative infection with human metapneumovirus could be prevented in paediatric cardiac high-risk patients by prophylactic hygiene intervention.

Item Type:

Journal Article

Creators:

Creators	Email	ORCID	ORCID Put Code
Leister, Nicolas	UNSPECIFIED	orcid.org/0000-0003-1932-0701	UNSPECIFIED
Commotio, Simone	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Menzel, Christoph	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Yucetepe, Sirin	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Ulrichs, Christoph	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Wendt, Stefanie	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Dedden, Christoph	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED
Trieschmann, Uwe	UNSPECIFIED	orcid.org/0000-0003-2529-9005	UNSPECIFIED
Hannes, Tobias	UNSPECIFIED	UNSPECIFIED	UNSPECIFIED