Universität zu Köln

Das, Suman G., Krug, Joachim and Mungan, Muhittin (2022). Driven Disordered Systems Approach to Biological Evolution in Changing Environments. Phys. Rev. X, 12 (3). COLLEGE PK: AMER PHYSICAL SOC. ISSN 2160-3308

Full text not available from this repository.

Abstract

Biological evolution of a population is governed by the fitness landscape, which is a map from genotype to fitness. However, a fitness landscape depends on the organism's environment, and evolution in changing environments is still poorly understood. We study a particular model of antibiotic resistance evolution in bacteria where the antibiotic concentration is an environmental parameter and the fitness landscapes incorporate trade-offs between adaptation to low and high antibiotic concentration. With evolutionary dynamics that follow fitness gradients, the evolution of the system under slowly changing antibiotic concentration resembles the athermal dynamics of disordered physical systems under external drives. Exploiting this resemblance, we show that our model can be described as a system with interacting hysteretic elements. As in the case of the driven disordered systems, adaptive evolution under antibiotic concentration cycling is found to exhibit hysteresis loops and memory formation. We derive a number of analytical results for quasistatic concentration changes. We also perform numerical simulations to study how these effects are modified under driving protocols in which the concentration is changed in discrete steps. Our approach provides a general framework for studying motifs of evolutionary dynamics in biological systems in a changing environment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Das, Suman G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Mungan, Muhittin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-665153
DOI:	10.1103/PhysRevX.12.031040
Journal or Publication Title:	Phys. Rev. X
Volume:	12
Number:	3
Date:	2022
Publisher:	AMER PHYSICAL SOC
Place of Publication:	COLLEGE PK
ISSN:	2160-3308
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIBIOTIC-RESISTANCE; FITNESS LANDSCAPES; ADAPTIVE WALKS; EPISTASIS; PREDICTABILITY; PERSPECTIVE; ADAPTATION; DYNAMICS; GENES; COSTS Multiple languages Physics, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66515