Universität zu Köln

Pechmann, Matthias ORCID: 0000-0002-0043-906X and Prpic, Nikola-Michael (2022). The T-box gene optomotor-blind organizes proximodistal leg patterning in the beetle Tribolium castaneum by repressing dorsal Dpp pathway activity. Dev. Biol., 482. S. 124 - 135. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-564X

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Abstract

Leg axis formation in Drosophila is organized by Wingless (Wg) and Decapentaplegic (Dpp) that control a number of downstream factors to pattern the dorsoventral (DV) and proximodistal (PD) axis. The T-box genes are important downstream factors mainly involved in dorsoventral leg axis formation. The ventral side is specified by H15 and midline, whereas optomotor-blind (omb) and Dorsocross (Doc1) are factors to specify dorsal cell fates. We show here that omb also organizes PD leg axis patterning in the beetle Tribolium castaneum. In the legs, Tc-omb is expressed along the dorsal side and represses ventral factors like wg and H15. Intriguingly, removing Tc-omb function leads to the activation of the Dpp pathway along the dorsal side of the legs, thus mimicking normal dpp expression in Drosophila. Dpp activity along the dorsal side leads to altered expression of proximal-distal patterning genes such as Distal-less (Dll) and dachshund (dac). Our results indicate a cell-autonomous activation of Dll and repression of dac by dpp. These findings are compatible with the cross-regulatory cascade model of proximal-distal leg imaginal disc patterning of Drosophila.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pechmann, Matthias UNSPECIFIED orcid.org/0000-0002-0043-906X UNSPECIFIED Prpic, Nikola-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-665201
DOI:	10.1016/j.ydbio.2021.12.008
Journal or Publication Title:	Dev. Biol.
Volume:	482
Page Range:	S. 124 - 135
Date:	2022
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-564X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROXIMAL-DISTAL AXIS; LONG-RANGE ACTION; DROSOPHILA LEG; GRADIENT FORMATION; MEDIAL FATES; WINGLESS; H15; SPECIFICATION; MELANOGASTER; MORPHOGENS Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66520