Universität zu Köln

Wang, Ruixun, Leite, Daniel J., Karadas, Linda, Schiffer, Philipp H. and Pechmann, Matthias (2023). FGF signalling is involved in cumulus migration in the common house spider Parasteatoda tepidariorum. Dev. Biol., 494. S. 35 - 46. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-564X

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Abstract

Cell migration is a fundamental component during the development of most multicellular organisms. In the early spider embryo, the collective migration of signalling cells, known as the cumulus, is required to set the dorso-ventral body axis.Here, we show that FGF signalling plays an important role during cumulus migration in the spider Parasteatoda tepidariorum. Spider embryos with reduced FGF signalling show reduced or absent cumulus migration and display dorsoventral patterning defects. Our study reveals that the transcription factor Ets4 regulates the expression of several FGF signalling components in the cumulus. In conjunction with a previous study, we show that the expression of fgf8 in the germ-disc is regulated via the Hedgehog signalling pathway. We also demonstrate that FGF signalling influences the BMP signalling pathway activity in the region around cumulus cells. Finally, we show that FGFR signalling might also influence cumulus migration in basally branching spiders and we propose that fgf8 might act as a chemo-attractant to guide cumulus cells towards the future dorsal pole of the spider embryo.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Ruixun UNSPECIFIED UNSPECIFIED UNSPECIFIED Leite, Daniel J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Karadas, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Schiffer, Philipp H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pechmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-665558
DOI:	10.1016/j.ydbio.2022.11.009
Journal or Publication Title:	Dev. Biol.
Volume:	494
Page Range:	S. 35 - 46
Date:	2023
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-564X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MECHANICAL-STRESS; CELL-MIGRATION; GROWTH; DROSOPHILA; ALIGNMENT; GENE; AXIS; DPP; SPECIFICATION; EXPRESSION Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66555