Universität zu Köln

Moehn, Nora, Grote-Levi, Lea, Hopfner, Franziska ORCID: 0000-0001-6524-0281, Eiz-Vesper, Britta, Maecker-Kolhoff, Britta, Warnke, Clemens ORCID: 0000-0002-3510-9255, Suehs, Kurt-Wolfram, Wattjes, Mike P., Hoeglinger, Guenter U. and Skripuletz, Thomas ORCID: 0000-0001-8550-335X (2022). Innovative therapeutic concepts of progressive multifocal leukoencephalopathy. J. Neurol., 269 (5). S. 2403 - 2414. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

Full text not available from this repository.

Abstract

Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the brain-caused by human polyomavirus 2. It affects patients whose immune system is compromised by a corresponding underlying disease or by drugs. Patients with an underlying lymphoproliferative disease have the worst prognosis with a mortality rate of up to 90%. Several therapeutic strategies have been proposed but failed to show any benefit so far. Therefore, the primary therapeutic strategy aims to reconstitute the impaired immune system to generate an effective endogenous antiviral response. Recently, anti-PD-1 antibodies and application of allogeneic virus-specific T cells demonstrated promising effects on the outcome in individual PML patients. This article aims to provide a detailed overview of the literature with a focus on these two treatment approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moehn, Nora UNSPECIFIED UNSPECIFIED UNSPECIFIED Grote-Levi, Lea UNSPECIFIED UNSPECIFIED UNSPECIFIED Hopfner, Franziska UNSPECIFIED orcid.org/0000-0001-6524-0281 UNSPECIFIED Eiz-Vesper, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Maecker-Kolhoff, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnke, Clemens UNSPECIFIED orcid.org/0000-0002-3510-9255 UNSPECIFIED Suehs, Kurt-Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Wattjes, Mike P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoeglinger, Guenter U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Skripuletz, Thomas UNSPECIFIED orcid.org/0000-0001-8550-335X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-666645
DOI:	10.1007/s00415-021-10952-5
Journal or Publication Title:	J. Neurol.
Volume:	269
Number:	5
Page Range:	S. 2403 - 2414
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEMATOPOIETIC-CELL TRANSPLANTATION; JC VIRUS; BK VIRUS; T-CELLS; RECIPIENTS; PATIENT; PML; IMMUNOTHERAPY; INTERLEUKIN-2; CYTOMEGALOVIRUS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66664