Universität zu Köln

Meyer, Meike ORCID: 0000-0002-5708-3981, Ruebsteck, Esra, Dewald, Felix, Klein, Florian ORCID: 0000-0003-1376-1792, Lehmann, Clara, Huenseler, Christoph and Weber, Lutz Thorsten (2022). Clinical Aspects of the Subsequent SARS-CoV-2 Waves in Children from 2020 to 2022-Data from a Local Cohort in Cologne, Germany (n=21,635). Viruses-Basel, 14 (8). BASEL: MDPI. ISSN 1999-4915

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Abstract

Almost two and a half years after the appearance of the first cases of SARS-CoV-2 in December 2019, more than 500 million people have been infected with SARS-CoV-2 and over 6 million have died of it worldwide. In terms of the pediatric cohort, it already became evident at an early stage that the infection causes milder symptoms in children and rarely runs a fatal course. Objective: This work presents data gathered over a period of over two years in patients between the age of 0 and 18 years. The aim is to provide information on the clinical aspects of the five different SARS-CoV-2 waves. Methods: Between 13 March 2020 and 22 April 2022, all nucleic acid amplification tests (NAATs) of children who received a swab for SARS-CoV-2 at our clinic were included. Data were collected on standardized questionnaires. The analysis of the data was anonymized and retrospective. Results: We investigated 21,635 NAATs, of which 1028 of the tests were positive (4.8%). The highest rate of positive results was observed in the fifth wave (541/2.292 NAATs (23.6%)). Most of the children who were hospitalized were hospitalized in wave three (22.9%). The availability of a vaccine was followed by a decrease in positive NAATs in the corresponding age group thereafter. Conclusions: These data underline the fact that children infected with SARS-CoV-2, regardless of which VOC, are often only mildly affected. Vaccinations seem to remain the key to avoid massive numbers of infected people and a potential collapse of the healthcare systems.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, Meike UNSPECIFIED orcid.org/0000-0002-5708-3981 UNSPECIFIED Ruebsteck, Esra UNSPECIFIED UNSPECIFIED UNSPECIFIED Dewald, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED Lehmann, Clara UNSPECIFIED UNSPECIFIED UNSPECIFIED Huenseler, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Lutz Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-666941
DOI:	10.3390/v14081607
Journal or Publication Title:	Viruses-Basel
Volume:	14
Number:	8
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1999-4915
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LABORATORY-CONFIRMED COVID-19-COVID-NET; 14 STATES; HOSPITALIZATIONS Multiple languages Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66694