Universität zu Köln

Longarini, Edoardo Jose and Matic, Ivan ORCID: 0000-0003-0170-7991 (2022). The fast-growing business of Serine ADP-ribosylation. DNA Repair, 118. AMSTERDAM: ELSEVIER. ISSN 1568-7856

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Abstract

ADP-ribosylation (ADPr) is a widespread post-translational modification (PTM) spanning all kingdoms of life. It is employed by bacteria and viruses in their war against the host, and by eukaryotes to regulate many physiological processes, across almost all cellular compartments. PARP1, the founding member of the PARP family, is an early sensor of single- and double-strand breaks and catalyzes ADPr to mediate DNA damage repair. The recent discovery of Serine-ADPr and the PARP1 accessory factor HPF1 has brought a momentous change to the field. Bolstered by innovative ways to study ADPr, new and exciting research directions are rapidly emerging. In this review we explore our understanding of the HPF1/PARP1-mediated ADPr signaling pathway in DNA damage. We focus on the mechanistic steps leading to Serine-ADPr and its relevance in the DNA damage response. We discuss important technological advances that have enabled a nuanced study of Serine-ADPr, and conclude with an overview of the role of PARP inhibitors in cancer therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Longarini, Edoardo Jose UNSPECIFIED UNSPECIFIED UNSPECIFIED Matic, Ivan UNSPECIFIED orcid.org/0000-0003-0170-7991 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-668017
DOI:	10.1016/j.dnarep.2022.103382
Journal or Publication Title:	DNA Repair
Volume:	118
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1568-7856
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STRAND BREAK REPAIR; DNA-REPAIR; POLY(ADP-RIBOSE) POLYMERASE; MASS-SPECTROMETRY; PARP INHIBITION; SYNTHETIC LETHALITY; CHROMATIN-STRUCTURE; CHEMICAL BIOLOGY; STRUCTURAL BASIS; EXCISION-REPAIR Multiple languages Genetics & Heredity; Toxicology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66801