Universität zu Köln

Estler, Bent ORCID: 0000-0002-2043-4557, Rudolph, Volker, Seleznova, Yana ORCID: 0000-0001-7260-6384, Shukri, Arim, Stock, Stephanie and Mueller, Dirk . Cost-effectiveness of the MitraClip device in German heart failure patients with secondary mitral regurgitation. Eur. J. Health Econ.. NEW YORK: SPRINGER. ISSN 1618-7601

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Abstract

Aim To evaluate the cost-effectiveness of the MitraClip device (MitraClip) in addition to optimal medical therapy (OMT) in patients with heart failure and secondary mitral regurgitation in Germany. Methods and results A model-based economic evaluation was performed to estimate the incremental cost per quality-adjusted life-years (QALYs) for patients with a moderate-to-severe or severe secondary mitral regurgitation receiving MitraClip plus OMT compared with OMT alone from the statutory health insurance (SHI) perspective. Transition probabilities, data on survival rates, and hospitalization rates were obtained from the COAPT trial, a randomized-controlled multicenter trial. Data on health utility and costs were taken from published evidence. To assess parameter uncertainty, several deterministic and probabilistic sensitivity analyses were performed. The incremental costs per QALY gained were (sic) 59,728 (costs/incremental life years gained: (sic) 42,360). The results were most sensitive to the transition probabilities and the hospitalization rates. The probabilistic sensitivity analysis showed that the MitraClip strategy was cost-effective with a probability of 80% at a willingness-to-pay threshold of (sic) 67,000/QALY. Conclusions Depending on the willingness-to-pay threshold, for patients with heart failure and a moderate-to-severe or severe secondary mitral regurgitation the MitraClip can be cost-effective from the perspective of the German SHI. [GRAPHICS] .

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Estler, Bent UNSPECIFIED orcid.org/0000-0002-2043-4557 UNSPECIFIED Rudolph, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Seleznova, Yana UNSPECIFIED orcid.org/0000-0001-7260-6384 UNSPECIFIED Shukri, Arim UNSPECIFIED UNSPECIFIED UNSPECIFIED Stock, Stephanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-668151
DOI:	10.1007/510198-022-01476-4
Journal or Publication Title:	Eur. J. Health Econ.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1618-7601
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC RESYNCHRONIZATION THERAPY; NETWORK Multiple languages Economics; Health Policy & Services Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66815