Affeldt, Patrick ORCID: 0000-0002-3075-0473, Koehler, Felix Carlo ORCID: 0000-0001-9269-7420, Brensing, Karl August, Gies, Martin, Platen, Eva ORCID: 0000-0003-1621-0232, Adam, Vivien, Butt, Linus, Grundmann, Franziska ORCID: 0000-0002-5766-7477, Heger, Eva, Hinrichs, Steffen, Kalisch, Nils, Oehm, Simon, Steger, Gertrud, Wirtz, Maike, Benzing, Thomas ORCID: 0000-0003-0512-1066, Stippel, Dirk ORCID: 0000-0002-1107-0907, Klein, Florian ORCID: 0000-0003-1376-1792, Kurschat, Christine ORCID: 0000-0002-3646-9471, Mueller, Roman-Ulrich and Di Cristanziano, Veronica (2022). Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients. Viruses-Basel, 14 (12). BASEL: MDPI. ISSN 1999-4915

Full text not available from this repository.

Abstract

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a serious hazard for hemodialysis (HD) patients and kidney transplant (KTX) recipients as they suffer from an impaired immune response to SARS-CoV-2 vaccination. In addition, a definition of SARS-CoV-2 IgG titer that indicates a sufficient immune response, especially against new omicron variants, is urgently needed. In the present study, the immune response to either a third or a fourth dose of a mRNA vaccine was investigated in 309 dialysis and 36 KTX patients. SARS-CoV-2 IgG titer thresholds indicating neutralizing activity against wild type (WT) and the omicron variant BA.1 were quantified. After four vaccine doses, a high-neutralizing activity against WT was evidenced in HD patients, whereas the neutralizing rate against BA.1 was significant lower. Concerning KTX recipients, humoral and cellular immune responses after a third vaccination were still highly impaired. This calls for modified omicron-targeting vaccines.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Affeldt, PatrickUNSPECIFIEDorcid.org/0000-0002-3075-0473UNSPECIFIED
Koehler, Felix CarloUNSPECIFIEDorcid.org/0000-0001-9269-7420UNSPECIFIED
Brensing, Karl AugustUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gies, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Platen, EvaUNSPECIFIEDorcid.org/0000-0003-1621-0232UNSPECIFIED
Adam, VivienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butt, LinusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grundmann, FranziskaUNSPECIFIEDorcid.org/0000-0002-5766-7477UNSPECIFIED
Heger, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinrichs, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kalisch, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oehm, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steger, GertrudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wirtz, MaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Benzing, ThomasUNSPECIFIEDorcid.org/0000-0003-0512-1066UNSPECIFIED
Stippel, DirkUNSPECIFIEDorcid.org/0000-0002-1107-0907UNSPECIFIED
Klein, FlorianUNSPECIFIEDorcid.org/0000-0003-1376-1792UNSPECIFIED
Kurschat, ChristineUNSPECIFIEDorcid.org/0000-0002-3646-9471UNSPECIFIED
Mueller, Roman-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Di Cristanziano, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-668981
DOI: 10.3390/v14122646
Journal or Publication Title: Viruses-Basel
Volume: 14
Number: 12
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 1999-4915
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANTIBODIESMultiple languages
VirologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/66898

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item