Universität zu Köln

Schiefer, Sabine, Wirsik, Naita Maren, Kalkum, Eva, Seide, Svenja Elisabeth, Nienhueser, Henrik, Mueller, Beat, Billeter, Adrian, Buechler, Markus W., Schmidt, Thomas and Probst, Pascal ORCID: 0000-0002-0895-4015 (2022). Systematic Review of Prognostic Role of Blood Cell Ratios in Patients with Gastric Cancer Undergoing Surgery. Diagnostics, 12 (3). BASEL: MDPI. ISSN 2075-4418

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Abstract

Various blood cell ratios exist which seem to have an impact on prognosis for resected gastric cancer patients. The aim of this systematic review was to investigate the prognostic role of blood cell ratios in patients with gastric cancer undergoing surgery in a curative attempt. A systematic literature search in MEDLINE (via PubMed), CENTRAL, and Web of Science was performed. Information on survival and cut-off values from all studies investigating any blood cell ratio in resected gastric cancer patients were extracted. Prognostic significance and optimal cut-off values were calculated by meta-analyses and a summary of the receiver operating characteristic. From 2831 articles, 65 studies investigated six different blood cell ratios (prognostic nutritional index (PNI), lymphocyte to monocyte ratio (LMR), systemic immune-inflammation index (SII), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)). There was a significant association for the PNI and NLR with overall survival and disease-free survival and for LMR and NLR with 5-year survival. The used cut-off values had high heterogeneity. The available literature is flawed by the use of different cut-off values hampering evidence-based patient treatment and counselling. This article provides optimal cut-off values recommendations for future research.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schiefer, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirsik, Naita Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalkum, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Seide, Svenja Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Nienhueser, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Beat UNSPECIFIED UNSPECIFIED UNSPECIFIED Billeter, Adrian UNSPECIFIED UNSPECIFIED UNSPECIFIED Buechler, Markus W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Probst, Pascal UNSPECIFIED orcid.org/0000-0002-0895-4015 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669051
DOI:	10.3390/diagnostics12030593
Journal or Publication Title:	Diagnostics
Volume:	12
Number:	3
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2075-4418
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEUTROPHIL-LYMPHOCYTE RATIO; LONG-TERM OUTCOMES; NUTRITIONAL INDEX; PREOPERATIVE NEUTROPHIL; PREDICTS SURVIVAL; CURATIVE RESECTION; MONOCYTE RATIO; INFLAMMATION; ADENOCARCINOMA; AGGRESSIVENESS Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66905