Universität zu Köln

Grevenstein, David, Schafigh, Darius, Oikonomidis, Stavros, Eysel, Peer, Brochhausen, Christoph, Spies, Christian Karl and Oppermann, Johannes (2022). Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation. Technol. Health Care, 30 (3). S. 725 - 734. AMSTERDAM: IOS PRESS. ISSN 1878-7401

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Abstract

BACKGROUND: Lesions of articular cartilage represent a crucial risk factor for the early development of osteoarthritis. Autologous chondrocyte implantation (ACI) is a well-established procedure in therapy of those lesions in the knee. The aim of the presented study is to detect differences in short-term radiological outcome depending on defect localization (femoral condyle vs. retropatellar) after spheroid-based ACI. OBJECTIVE: This study aimed to demonstrate that radiological outcome after spheroid-based ACI in the knee is independent of defect localization. METHODS: MRI-scans after retropatellar ACI and ACI of the medial/lateral femoral condyle, with a preoperative Outerbridge grade of III or IV were evaluated regarding MOCART 2.0. RESULTS: The mean defect-size was 5.0 +/- 1.8 cm(2), with a minimum size of 2 cm(2) and a maximum size of 9 cm(2). Scans were performed 7.7 months (+/- 3.1 months) postoperatively. The mean MOCART 2.0 score was 78.5 +/- 15.6. No statistically significant influence neither of the localization (p = 0.159), the gender (p = 0.124) nor defect size (< 5 cm(2) vs. > 5 cm(2); p = 0.201) could be observed. CONCLUSIONS: The presented data demonstrate good to excellent radiological short-term results after spheroid-based ACI. Data indicates, that at least radiological results are independent of gender, defect-size and defect-localization.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Grevenstein, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Schafigh, Darius UNSPECIFIED UNSPECIFIED UNSPECIFIED Oikonomidis, Stavros UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, Peer UNSPECIFIED UNSPECIFIED UNSPECIFIED Brochhausen, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Spies, Christian Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Oppermann, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669092
DOI:	10.3233/THC-213066
Journal or Publication Title:	Technol. Health Care
Volume:	30
Number:	3
Page Range:	S. 725 - 734
Date:	2022
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1878-7401
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARTILAGE REPAIR TISSUE; OSTEOCHONDRAL DEFECTS; FOLLOW-UP; PERIOSTEUM; OUTCOMES Multiple languages Health Care Sciences & Services; Engineering, Biomedical Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66909