Universität zu Köln

Leibold, Sandra, Lakshminarasimha, Amrutha Bagivalu, Gremse, Felix, Hammerschmidt, Matthias and Michel, Maximilian ORCID: 0000-0002-5910-5363 (2022). Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. PLoS One, 17 (5). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Obesity and metabolic syndrome are of increasing global concern. In order to understand the basic biology and etiology of obesity, research has turned to animals across the vertebrate spectrum including zebrafish. Here, we carefully characterize zebrafish in a long-term obesogenic environment as well as zebrafish that went through early lifetime caloric restriction. We found that long-term obesity in zebrafish leads to metabolic endpoints comparable to mammals including increased adiposity, weight, hepatic steatosis and hepatic lesions but not signs of glucose dysregulation or differences in metabolic rate or mitochondrial function. Malnutrition in early life has been linked to an increased likelihood to develop and an exacerbation of metabolic syndrome, however fish that were calorically restricted from five days after fertilization until three to nine months of age did not show signs of an exacerbated phenotype. In contrast, the groups that were shifted later in life from caloric restriction to the obesogenic environment did not completely catch up to the long-term obesity group by the end of our experiment. This dataset provides insight into a slowly exacerbating time-course of obesity phenotypes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Leibold, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Lakshminarasimha, Amrutha Bagivalu UNSPECIFIED UNSPECIFIED UNSPECIFIED Gremse, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammerschmidt, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Michel, Maximilian UNSPECIFIED orcid.org/0000-0002-5910-5363 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669605
DOI:	10.1371/journal.pone.0267933
Journal or Publication Title:	PLoS One
Volume:	17
Number:	5
Date:	2022
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPENSATORY GROWTH; ENERGY-EXPENDITURE; OXIDATIVE STRESS; INDUCED OBESITY; PRETERM BIRTH; INFANCY; LIFE; DEFICIENCY; DEPOSITION; RESISTANCE Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66960