Universität zu Köln

Zander, Thomas and Wagner, Anna Dorothea (2022). (Neo)Adjuvant Treatment of Locally Advanced Esophageal and Gastroesophageal Adenocarcinoma: Special Focus on Sex Differences. Cancers, 14 (4). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary Multimodal therapy is standard in locally advanced esophageal and gastroesophageal adenocarcinoma. Although substantial differences in incidence and outcome between women and men have been observed, no clear sex-specific treatment guide has been developed. In this summary, we described known sex differences focusing on locally advanced esophageal and gastroesophageal adenocarcinoma. Adenocarcinoma of the esophagus and gastroesophageal junction is a common disease. This disease is significantly more prevalent in men, although the main underlying risk factor has an equal sex distribution. In locally advanced disease, multimodal therapy has been developed as the standard in the western world. Neoadjuvant chemoradiotherapy or perioperative chemotherapy using the FLOT regimen was established as the standard. Most recently, adjuvant immunotherapy after neoadjuvant chemoradiotherapy and surgery has been introduced into the multimodal therapy. Substantial sex-specific differences in outcome in multimodal therapy have been described in retrospective subgroup analysis. Further studies are warranted to dissect the sex-specific differences in these treatment regimens.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zander, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Anna Dorothea UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669631
DOI:	10.3390/cancers14041088
Journal or Publication Title:	Cancers
Volume:	14
Number:	4
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2072-6694
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHEMORADIOTHERAPY PLUS SURGERY; OPEN-LABEL; NEOADJUVANT CHEMORADIOTHERAPY; PERIOPERATIVE CHEMOTHERAPY; PREOPERATIVE CHEMORADIATION; ESOPHAGOGASTRIC CANCER; POOLED ANALYSIS; PHASE-II; FLUOROURACIL; MULTICENTER Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66963