Universität zu Köln

Breitschwerdt, Sven ORCID: 0000-0001-6585-1605, Schwarze-Zander, Carolynne, Al Tayy, Ahmad, Mutevelli, Julia, Wasmuth, Jan-Christian, Rockstroh, Jurgen K. and Boesecke, Christoph (2022). Implementation of EACS vaccination recommendations among people living with HIV. Infection, 50 (6). S. 1491 - 1498. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1439-0973

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Abstract

Objectives With modern combination antiretroviral Treatment (cART) a normal life expectancy among people living with HIV (PLWH) has become reality if started early enough prior to the onset of more pronounced immunodeficiency. Therefore, prevention measures against other infectious diseases among this vulnerable group have gained increased attention. Indeed, the EACS guidelines recommend vaccinations against HAV, HBV, HPV, Influenza, Neisseria meningitidis, Streptococcus pneumoniae and VZV in HIV-infected adults. Methods All PLWH under cART attending our ID outpatient clinic between April to June 2018, were assessed during consultation for vaccination status regarding pneumococcus, Hepatitis A and B, influenza, varicella, meningococcus and HPV using a pre-defined questionnaire, vaccination certificates and medical records. In addition, the cohort database was screened for Hepatitis A and B serology and HIV surrogate markers. Results A total of 305 PLWH (82.3% male, 17.7% female) was included, median age was 48 years (IQR 47-51). Median CD4 + T cell count was 543 (IQR 304-770), and for 297 (97.4%) PLWH CD4 + T cell count was >= 200/ul. The viral load was undetectable (< 40 copies/ml) in 289 (94.8%) cases. Highest vaccination rates were observed for HAV (87.4%), Streptococcus pneumoniae (77.4%) and Influenza (76.5%). 64.3% PLWH got vaccinated against HBV, whereas VZV vaccination only played a minor role, in the context of the high rate of cleared infections (99.0%). Lowest vaccination rates were detected for HPV (0%) and Neisseria meningitidis (3.0%). Conclusions Our data suggest that vaccination rates among PLWH are higher compared to the general German population. Implementation of EACS guidelines into daily routine though is not fully executed and the need for improving vaccination rates has to be emphasized. Centrally organized vaccination registers as well as electronic medical records could be helpful tools to detect a lack of vaccination coverage and send digital vaccination reminders particularly among risk groups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Breitschwerdt, Sven UNSPECIFIED orcid.org/0000-0001-6585-1605 UNSPECIFIED Schwarze-Zander, Carolynne UNSPECIFIED UNSPECIFIED UNSPECIFIED Al Tayy, Ahmad UNSPECIFIED UNSPECIFIED UNSPECIFIED Mutevelli, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Wasmuth, Jan-Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, Jurgen K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boesecke, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-669827
DOI:	10.1007/s15010-022-01827-6
Journal or Publication Title:	Infection
Volume:	50
Number:	6
Page Range:	S. 1491 - 1498
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1439-0973
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFLUENZA VACCINATION; HEPATITIS-A; COVERAGE; HEALTH; ADULTS; PREDICTORS; MEN; SEX Multiple languages Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/66982