Universität zu Köln

Heiden, Petra, Weigel, Daniel Tim, Loucao, Ricardo, Hamisch, Christina, Guenduez, Enes M., Ruge, Maximilian, I, Kuhn, Jens ORCID: 0000-0002-4719-5293, Visser-Vandewalle, Veerle and Andrade, Pablo ORCID: 0000-0002-2596-7301 (2022). Connectivity in deep brain stimulation for self-injurious behavior: multiple targets for a common network? Front. Hum. Neurosci., 16. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1662-5161

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Abstract

Self-injurious behavior (SIB) is associated with diverse psychiatric conditions. Sometimes (e.g., in patients with autism spectrum disorder or acquired brain injuries), SIB is the most dominant symptom, severely restricting the psychosocial functioning and quality of life of the patients and inhibiting appropriate patient care. In severe cases, it can lead to permanent physical injuries or even death. Primary therapy consists of medical treatment and if implementable, behavioral therapy. For patients with severe SIB refractory to conventional therapy, neuromodulation can be considered as a last recourse. In scientific literature, several successful lesioning and deep brain stimulation targets have been described that can indicate a common underlying neuronal pathway. The objectives of this study were to evaluate the short- and long-term clinical outcome of patients with severe, therapy refractory SIB who underwent DBS with diverse underlying psychiatric disorders and to correlate these outcomes with the activated connectivity networks. We retrospectively analyzed 10 patients with SIB who underwent DBS surgery with diverse psychiatric conditions including autism spectrum disorder, organic personality disorder after hypoxic or traumatic brain injury or Tourette syndrome. DBS targets were chosen according to the underlying disorder, patients were either stimulated in the nucleus accumbens, amygdala, posterior hypothalamus, medial thalamus or ventrolateral thalamus. Clinical outcome was measured 6 months after surgery and at long-term follow-up after 10 or more years using the Early Rehabilitation Barthel index (ERBI) and time of restraint. Connectivity patterns were analyzed using normative connectome. Based on previous literature the orbitofrontal cortex, superior frontal gyrus, the anterior cingulate cortex, the amygdala and the hippocampus were chosen as regions of interest. This analysis showed a significant improvement in the functionality of the patients with DBS in the short- and long-term follow-up. Good clinical outcome correlated with higher connectivity to the amygdala and hippocampus. These findings may suggest a common pathway, which can be relevant when planning a surgical procedure in patients with SIB.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heiden, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Weigel, Daniel Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Loucao, Ricardo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamisch, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Guenduez, Enes M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruge, Maximilian, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, Jens UNSPECIFIED orcid.org/0000-0002-4719-5293 UNSPECIFIED Visser-Vandewalle, Veerle UNSPECIFIED UNSPECIFIED UNSPECIFIED Andrade, Pablo UNSPECIFIED orcid.org/0000-0002-2596-7301 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670024
DOI:	10.3389/fnhum.2022.958247
Journal or Publication Title:	Front. Hum. Neurosci.
Volume:	16
Date:	2022
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1662-5161
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTERIOR CAPSULOTOMY; AGGRESSION; MRI; NEUROBIOLOGY; AMYGDALOTOMY; INDIVIDUALS; DBS Multiple languages Neurosciences; Psychology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67002