Universität zu Köln

Hommelsen, Maximilian ORCID: 0000-0003-1972-0465, Viswanathan, Shivakumar ORCID: 0000-0002-7513-3778 and Daun, Silvia ORCID: 0000-0001-7342-1015 . Robustness of individualized inferences from longitudinal resting state EEG dynamics. Eur. J. Neurosci.. HOBOKEN: WILEY. ISSN 1460-9568

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Abstract

Tracking how individual human brains change over extended timescales is crucial to clinical scenarios ranging from stroke recovery to healthy aging. The use of resting state (RS) activity for tracking is a promising possibility. However, it is unresolved how a person's RS activity over time can be decoded to distinguish neurophysiological changes from confounding cognitive variability. Here, we develop a method to screen RS activity changes for these confounding effects by formulating it as a problem of change classification. We demonstrate a novel solution to change classification by linking individual-specific change to inter-individual differences. Individual RS-electroencephalography (EEG) was acquired over 5 consecutive days including task states devised to simulate the effects of inter-day cognitive variation. As inter-individual differences are shaped by neurophysiological differences, the inter-individual differences in RS activity on 1 day were analysed (using machine learning) to identify distinctive configurations in each individual's RS activity. Using this configuration as a decision rule, an individual could be re-identified from 2-s samples of the instantaneous oscillatory power spectrum acquired on a different day both from RS and confounded RS with a limited loss in accuracy. Importantly, the low loss in accuracy in cross-day versus same-day classification was achieved with classifiers that combined information from multiple frequency bands at channels across the scalp (with a concentration at characteristic fronto-central and occipital zones). Taken together, these findings support the technical feasibility of screening RS activity for confounding effects and the suitability of longitudinal RS for robust individualized inferences about neurophysiological change in health and disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hommelsen, Maximilian UNSPECIFIED orcid.org/0000-0003-1972-0465 UNSPECIFIED Viswanathan, Shivakumar UNSPECIFIED orcid.org/0000-0002-7513-3778 UNSPECIFIED Daun, Silvia UNSPECIFIED orcid.org/0000-0001-7342-1015 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670431
DOI:	10.1111/ejn.15673
Journal or Publication Title:	Eur. J. Neurosci.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1460-9568
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FUNCTIONAL CONNECTIVITY; STRUCTURAL CONNECTIVITY; MOTOR CORTEX; NETWORKS; ALPHA; FMRI; RECOVERY; VALIDATION; AMPLITUDE; MODELS Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67043