Universität zu Köln

Volp, Andreas, Schmitz, Jennifer, Bulitta, Michael, Raskopf, Esther, Acikel, Cengizhan and Mosges, Ralph (2022). Ivy leaves extract EA 575 in the treatment of cough during acute respiratory tract infections: meta-analysis of double-blind, randomized, placebo-controlled trials. Sci Rep, 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2045-2322

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Abstract

Ivy leaves extracts have been used successfully to treat acute cough, and data from well-controlled trials is accumulating. We present a meta-analysis of two double-blind, randomized, placebo-controlled trials. Patients with acute respiratory tract infection (ARTI) received ivy leaves dry extract EA 575 (n = 228) or placebo (n = 162) for 7 days, followed by a 7-day period without treatment. The main efficacy outcome was the Bronchitis Severity Score (BSS). Individual patient data meta-analyses were performed using mixed models for repeated measures, analysis of covariance and logistic ordinal regression. Significant BSS differences between EA 575 and placebo occurred already after 2 days and increased until treatment end, with BSS reductions of 8.6 +/- 0.2 and 6.2 +/- 0.2 (marginal means +/- SEM; p < 0.001). The score reduction for placebo after 7 days was comparable to that for EA 575 after 4 days. In the EA 575 group, the proportion of cough-free patients was 18.1% at treatment end and 56.2% at end of follow-up, compared to 9.3% and 25.6% for placebo, respectively. Adverse event rates for EA 575 and placebo were comparable. EA 575 reduces effectively the intensity of acute cough associated with ARTIs and leads to a significant acceleration of recovery. No safety signals were observed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Volp, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Bulitta, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Raskopf, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Acikel, Cengizhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mosges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670585
DOI:	10.1038/s41598-022-24393-1
Journal or Publication Title:	Sci Rep
Volume:	12
Number:	1
Date:	2022
Publisher:	NATURE PORTFOLIO
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRY EXTRACT; ALPHA-HEDERIN; ADULTS; BRONCHITIS; DIAGNOSIS; BURDEN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67058