Universität zu Köln

Dewald, Felix, Detmer, Susanne, Pirkl, Martin, Hellmich, Martin, Heger, Eva, Herrmann, Maximilian, Lehmann, Clara ORCID: 0000-0002-7042-1578, Zweigner, Janine and Klein, Florian ORCID: 0000-0003-1376-1792 (2022). Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections. J. Infect. Dis., 226 (10). S. 1721 - 1726. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6613

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Abstract

To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time. This study provides longitudinal data upon Omicron breakthrough infections in double-vaccinated and boostered individuals. While peak viral loads were reduced in boostered individuals, no difference was observed for the duration of SARS-CoV-2 detection between both groups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dewald, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Detmer, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Pirkl, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Heger, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Herrmann, Maximilian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Clara UNSPECIFIED orcid.org/0000-0002-7042-1578 UNSPECIFIED Zweigner, Janine UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Florian UNSPECIFIED orcid.org/0000-0003-1376-1792 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-670932
DOI:	10.1093/infdis/jiac290
Journal or Publication Title:	J. Infect. Dis.
Volume:	226
Number:	10
Page Range:	S. 1721 - 1726
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1537-6613
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Immunology; Infectious Diseases; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67093