Universität zu Köln

Wang, Maoren, Liu, Hanhan, Xia, Ning ORCID: 0000-0002-5553-1752, Li, Huige ORCID: 0000-0003-3458-7391, van Beers, Tim, Gericke, Adrian and Prokosch, Verena (2022). Intraocular Pressure-Induced Endothelial Dysfunction of Retinal Blood Vessels Is Persistent, but Does Not Trigger Retinal Ganglion Cell Loss. Antioxidants, 11 (10). BASEL: MDPI. ISSN 2076-3921

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Abstract

Research has been conducted into vascular abnormalities in the pathogenesis of glaucoma, but conclusions remain controversial. Our aim was to test the hypothesis that retinal endothelial dysfunction induced by elevated intraocular pressure (IOP) persists after IOP normalization, further triggering retinal ganglion cell (RGC) loss. High intraocular pressure (HP) was induced in mice by episcleral vein occlusion (EVO). Retinal vascular function was measured via video microscopy in vitro. The IOP, RGC and their axons survival, levels of oxidative stress and inflammation as well as vascular pericytes coverage, were determined. EVO caused HP for two weeks, which returned to baseline afterwards. Mice with HP exhibited endothelial dysfunction in retinal arterioles, reduced density of RGC and their axons, and loss of pericytes in retinal arterioles. Notably, these values were similar to those of mice with recovered IOP (RP). Levels of oxidative stress and inflammation were increased in HP mice but went back to normal in the RP mice. Our data demonstrate that HP induces persistent endothelial dysfunction in retinal arterioles, which persists one month after RP. Oxidative stress, inflammation, and loss of pericytes appear to be involved in triggering vascular functional deficits. Our data also suggest that retinal endothelial dysfunction does not affect RGC and their axon survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Maoren UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Hanhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Xia, Ning UNSPECIFIED orcid.org/0000-0002-5553-1752 UNSPECIFIED Li, Huige UNSPECIFIED orcid.org/0000-0003-3458-7391 UNSPECIFIED van Beers, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Gericke, Adrian UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokosch, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671381
DOI:	10.3390/antiox11101864
Journal or Publication Title:	Antioxidants
Volume:	11
Number:	10
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2076-3921
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY ANGLE-CLOSURE; OXIDATIVE STRESS; OCULAR HYPERTENSION; RAT MODEL; GLAUCOMA; IDENTIFICATION; MECHANISMS; GLUTAMATE; DENSITY; MARKER Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67138