Universität zu Köln

Milzi, Andrea ORCID: 0000-0001-7580-8029, Dettori, Rosalia, Lubberich, Richard Karl, Burgmaier, Kathrin, Marx, Nikolaus, Reith, Sebastian and Burgmaier, Mathias (2022). Quantitative Flow Ratio Is Related to Anatomic Left Main Stem Lesion Parameters as Assessed by Intravascular Imaging. J. Clin. Med., 11 (20). BASEL: MDPI. ISSN 2077-0383

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Abstract

Introduction: Previously, an association between anatomic left main stem (LMS) lesion parameters, as described by intravascular ultrasound (IVUS) and fractional flow reserve (FFR), was shown. Quantitative flow ratio (QFR) is a novel, promising technique which can assess functional stenosis relevance based only on angiography. However, as little is known about the relationship between anatomic LMS parameters and QFR, it was thus investigated in this study. Methods: In 53 patients with LMS disease, we tested the association between anatomic assessment using OCT (n = 28) or IVUS (n = 25) on the one hand and functional assessment as determined by QFR on the other hand. LMS-QFR was measured using a dedicated approach, averaging QFR over left anterior descending (LAD) and circumflex (LCX) and manually limiting segment of interest to LMS. Results: The minimal luminal area of the LMS (LMS-MLA) as measured by intravascular imaging showed a consistent correlation with QFR (R = 0.61, p < 0.001). QFR could predict a LMS-MLA < 6 mm(2) with very good diagnostic accuracy (AUC 0.919) and a LMS-MLA < 4.5 mm(2) with good accuracy (AUC 0.798). Similar results were obtained for other stenosis parameters. Conclusions: QFR might be a valuable tool to assess LMS disease. Further studies focusing on patient outcomes are needed to further validate the effectiveness of this approach.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Milzi, Andrea UNSPECIFIED orcid.org/0000-0001-7580-8029 UNSPECIFIED Dettori, Rosalia UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubberich, Richard Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmaier, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Marx, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Reith, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Burgmaier, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671589
DOI:	10.3390/jcm11206024
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	20
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PERCUTANEOUS CORONARY ANGIOPLASTY; BYPASS-SURGERY; DIAGNOSTIC-ACCURACY; RESERVE ASSESSMENT; RANDOMIZED-TRIAL; 5-YEAR OUTCOMES; ANGIOGRAPHY; STENOSIS; STENTS; REVASCULARIZATION Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67158