Universität zu Köln

Lau, Patrick ORCID: 0000-0002-7290-5875, Vico, Laurence ORCID: 0000-0002-2110-287X and Rittweger, Joern (2022). Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines? Biomedicines, 10 (2). BASEL: MDPI. ISSN 2227-9059

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Abstract

The dissociation of bone formation and resorption is an important physiological process during spaceflight. It also occurs during local skeletal unloading or immobilization, such as in people with neuromuscular disorders or those who are on bed rest. Under these conditions, the physiological systems of the human body are perturbed down to the cellular level. Through the absence of mechanical stimuli, the musculoskeletal system and, predominantly, the postural skeletal muscles are largely affected. Despite in-flight exercise countermeasures, muscle wasting and bone loss occur, which are associated with spaceflight duration. Nevertheless, countermeasures can be effective, especially by preventing muscle wasting to rescue both postural and dynamic as well as muscle performance. Thus far, it is largely unknown how changes in bone microarchitecture evolve over the long term in the absence of a gravity vector and whether bone loss incurred in space or following the return to the Earth fully recovers or partly persists. In this review, we highlight the different mechanisms and factors that regulate the humoral crosstalk between the muscle and the bone. Further we focus on the interplay between currently known myokines and osteokines and their mutual regulation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lau, Patrick UNSPECIFIED orcid.org/0000-0002-7290-5875 UNSPECIFIED Vico, Laurence UNSPECIFIED orcid.org/0000-0002-2110-287X UNSPECIFIED Rittweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-671894
DOI:	10.3390/biomedicines10020342
Journal or Publication Title:	Biomedicines
Volume:	10
Number:	2
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2227-9059
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DAYS BED REST; SKELETAL-MUSCLE; GROWTH-FACTOR; SPACE-FLIGHT; UNDERCARBOXYLATED OSTEOCALCIN; MYOGENIC DIFFERENTIATION; THERAPEUTIC TARGETS; SIGNALING PATHWAYS; MECHANICAL SIGNALS; SERUM SCLEROSTIN Multiple languages Biochemistry & Molecular Biology; Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67189