Universität zu Köln

Niecke, Alexander ORCID: 0000-0002-4042-6693, Peters, Klaus M., Alayli, Adrienne, Luengen, Markus, Pfaff, Holger ORCID: 0000-0001-9154-6575, Albus, Christian and Samel, Christina (2022). Health-related quality of life after 50 years in individuals with thalidomide embryopathy: Evidence from a German cross-sectional survey. Birth Defects Res., 114 (13). S. 714 - 725. HOBOKEN: WILEY. ISSN 2472-1727

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Abstract

Background As individuals with thalidomide embryopathy now reaching their 60's they undergo long-term sequelae of their prenatal damage and experience a wide range of secondary health problems, in particular chronic musculoskeletal pain, movement restrictions, and mental disorders. These health problems are having a negative impact on their life circumstances and their health-related quality of life (HRQOL). Objective The aim of this study was to determine the HRQOL in individuals with thalidomide embryopathy in comparison to individuals of the age-adjusted general population in Germany with and without chronic disease conditions (primary outcome). And, further explore the influence of impairment patterns, pain stage, and mental disorders on physical and mental dimensions of HRQOL (secondary outcome). Methods A cross-sectional survey of 202 individuals with thalidomide embryopathy from North Rhine-Westphalia/Germany was conducted, which gathered information about physical examinations including a standardized determination of the pain stage, a structured psychological interview, and the HRQOL. The final dataset was 186 cases for primary outcome. Results Individuals with thalidomide embryopathy (50.6 years, 55.9% females) show a significantly reduced physical HRQOL comparison to the age-adjusted German population with chronic diseases (physical component score; pcs: 33.4 vs. 45.3, p < .001). In addition, male individuals with thalidomide embryopathy show a significantly reduced mental HRQOL to their male counterparts in this comparison (mental component score; mcs: 45.0 vs. 50.0, p = .005). The subgroup analyses show that individuals with thalidomide embryopathy with quadruple impairment have a significantly lower physical HRQOL than those with hearing loss (pcs: 25.0 vs. 38.5; ci's not overlapping). Second, individuals with thalidomide embryopathy with severe compared to mild stages of pain have significantly poorer levels of physical and mental HRQOL (pcs: 25.8 vs. 37.7, ci not overlapping; mcs: 40.4 vs. 51.8, ci's not overlapping). And, individuals with thalidomide embryopathy without a mental disorder show a high mental HRQOL (mcs: 53.2), while in comparison to the total sample those with somatoform and personality disorders have a significantly reduced physical HRQOL (pcs: 27.5 and 24.8; both ci's not overlapping), and those with depressive disorders have a significant reduced mental HRQOL (mcs: 38.0 vs. 45.8, ci's not overlapping). Conclusions A longitudinal decreasing HRQOL in individuals with thalidomide embryopathy is known, as well as high prevalence of mental disorders and chronic pain syndromes. This study shows a strong association between these two influencing factors and a poor HRQOL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Niecke, Alexander UNSPECIFIED orcid.org/0000-0002-4042-6693 UNSPECIFIED Peters, Klaus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alayli, Adrienne UNSPECIFIED UNSPECIFIED UNSPECIFIED Luengen, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfaff, Holger UNSPECIFIED orcid.org/0000-0001-9154-6575 UNSPECIFIED Albus, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Samel, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-672060
DOI:	10.1002/bdr2.2051
Journal or Publication Title:	Birth Defects Res.
Volume:	114
Number:	13
Page Range:	S. 714 - 725
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	2472-1727
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RECOGNITION; DISORDERS; DISEASES; HISTORY; SF-36 Multiple languages Developmental Biology; Toxicology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67206