Universität zu Köln

Kipfmueller, Florian ORCID: 0000-0002-7414-757X, Akkas, Suemeyra, Pugnaloni, Flaminia ORCID: 0000-0001-9509-6778, Bo, Bartolomeo, Lemloh, Lotte, Schroeder, Lukas, Gembruch, Ulrich ORCID: 0000-0001-8284-4669, Geipel, Annegret, Berg, Christoph, Heydweiller, Andreas and Mueller, Andreas (2022). Echocardiographic Assessment of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia Using Pulmonary Artery Flow Characteristics. J. Clin. Med., 11 (11). BASEL: MDPI. ISSN 2077-0383

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Abstract

Background: Assessment of pulmonary hypertension (PH) is essential in neonates with congenital diaphragmatic hernia (CDH). Echocardiography is widely established to quantify PH severity, but currently used parameters have inherent limitations. The aim of our study was to investigate the prognostic utility of the index of the pulmonary artery acceleration time to the right ventricular ejection time (PAAT:ET) in CDH neonates assessed using echocardiography. Methods: PAAT:ET values were prospectively measured in CDH neonates on admission, on day of life (DOL) 2 and DOL 5-7. Optimal cut-off values to predict mortality and need for ECMO were calculated and PAAT:ET values were compared between non-ECMO survivors, ECMO-survivors, and ECMO-non-survivors. Results: 87 CDH neonates were enrolled and 39 patients required ECMO therapy. At baseline, PAAT:ET values were significantly lower in ECMO patients compared to non-ECMO patients (p < 0.001). ECMO survivors and ECMO non-survivors had similar values at baseline (p = 0.967) and DOL 2 (p = 0.124) but significantly higher values at DOL 5-7 (p = 0.003). Optimal PAAT:ET cut-off for predicting ECMO was 0.290 at baseline and 0.310 for predicting non-survival in patients on ECMO at DOL 5-7. Conclusion: PAAT:ET is a feasible parameter for early risk assessment in CDH neonates.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kipfmueller, Florian UNSPECIFIED orcid.org/0000-0002-7414-757X UNSPECIFIED Akkas, Suemeyra UNSPECIFIED UNSPECIFIED UNSPECIFIED Pugnaloni, Flaminia UNSPECIFIED orcid.org/0000-0001-9509-6778 UNSPECIFIED Bo, Bartolomeo UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemloh, Lotte UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Heydweiller, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-672545
DOI:	10.3390/jcm11113038
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	11
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTRACORPOREAL LIFE-SUPPORT; CARDIAC DYSFUNCTION; NATRIURETIC PEPTIDE; ACCELERATION TIME; MANAGEMENT; INFANTS; EUROPE Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67254