Universität zu Köln

Behringer, K., Oertel, M., Rueffer, J. U. and Borchmann, P. (2022). Disease- and treatment-related late sequelae in Hodgkin lymphoma. Onkologie, 28 (10). S. 914 - 923. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2731-7234

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Abstract

Background Given the impressive long-term remission rates in recent years, current clinical research focuses on late sequelae beyond diagnosis and treatment of Hodgkin lymphoma (HL). Objectives Following treatment of HL, early recognition and treatment of late sequelae is important. Comprehensive care should also be offered to recovering patients in the follow-up phase. Results In the long term, the general overall quality of life of HL patients and survivors is lower than in controls of the same age. The development of cancer-related fatigue (CRF), which can persist long after primary treatment, prevents long-term survivors from continuing their previous lives and returning to work. Other complications include the development of second malignant neoplasms (SMN), which represent a significant mortality risk for former patients. Organ toxicities include cardiac, pulmonary, and gonadal damage. The latter are particularly relevant for young survivors who have not yet completed family planning. Before initiating therapy, the patients should be informed about the possibility of fertility-preserving measures. Conclusion In view of persistent impairment of quality of life and the negative impact of CRF on the employment of former HL patients, models for targeted care during therapy and in the aftercare phase should urgently be further developed. Recent clinical trials in HL aim at balancing efficacy against acute and chronic sequelae.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Behringer, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Oertel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rueffer, J. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-672782
DOI:	10.1007/s00761-022-01173-0
Journal or Publication Title:	Onkologie
Volume:	28
Number:	10
Page Range:	S. 914 - 923
Date:	2022
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	2731-7234
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER-RELATED FATIGUE; COGNITIVE-BEHAVIOR THERAPY; DETUDE-DES-LYMPHOMES; LONG-TERM SURVIVORS; QUALITY-OF-LIFE; BREAST-CANCER; FERTILITY PRESERVATION; GONADAL-FUNCTION; EUROPEAN-ORGANIZATION; YOUNG-WOMEN Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67278