Universität zu Köln

Altay, Lebriz, Lemke, Julia, Schroeder-Braunstein, Jutta, Gietzelt, Caroline ORCID: 0000-0002-9145-7385, Sitnilska, Vasilena, Schaub, Friederike, Cursiefen, Claus, Enders, Philip ORCID: 0000-0002-9527-4957 and Fauser, Sascha (2022). Ocular and Systemic Complement Activation during Anti-Vascular Endothelial Growth Factor Treatment and Age-Related Eye Disease Study 2 Dietary Supplementation in Neovascular Age-Related Macular Degeneration. Ophthalmologica, 245 (3). S. 258 - 265. BASEL: KARGER. ISSN 1423-0267

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Abstract

Purpose: The aim of this study was to investigate the influence of dietary supplementation using Age-Related Eye Disease Study 2 (AREDS2) on complement activation in patients with neovascular age-related macular degeneration (nAMD) under ongoing treatment. Methods: In this prospective, single-center, controlled, open-label investigator-initiated trial, eligible nAMD patients were randomized at a ratio of 1:1 in 2 groups: those with and without dietary AREDS2 supplementation for 4 weeks. Zinc, plasma, and aqueous humor (AH) complement levels were quantified via enzyme-linked immunosorbent assays. Results: Fifty of 62 enrolled patients completed the trial (AREDS2 n = 27, controls n = 23). Systemic zinc and complement levels were not different at baseline between the 2 groups (p > 0.1). At the final visit, systemic zinc levels were significantly higher in the AREDS2 group (10.16 +/- 2.08 mu mol/L; 8.66 +/- 1.17 mu mol/L; p = 0.007), whereas systemic and AH complement levels were not different (p > 0.1). In both groups, no significant change was observed in systemic levels of C3, C3a, FH, FI, and sC5b-9 (p > 0.1). Only systemic complement component Ba showed an increase from baseline to the end visit (p = 0.01). This increase was higher in the control group (p = 0.02) than in the AREDS2 group (p = 0.23). Conclusions: Short-term dietary AREDS2 supplementation leads to a significant increase in systemic zinc levels without any influence on complement activation levels.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Altay, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder-Braunstein, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Gietzelt, Caroline UNSPECIFIED orcid.org/0000-0002-9145-7385 UNSPECIFIED Sitnilska, Vasilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED orcid.org/0000-0002-9527-4957 UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-672912
DOI:	10.1159/000516885
Journal or Publication Title:	Ophthalmologica
Volume:	245
Number:	3
Page Range:	S. 258 - 265
Date:	2022
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0267
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BETA-CAROTENE; ZINC; CFH; ANTIOXIDANTS; ASSOCIATION; GENOTYPES; DRUSEN; INFLAMMATION Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67291