Universität zu Köln

Corrado, Mauro ORCID: 0000-0002-0617-3274 and Pearce, Erika L. (2022). Targeting memory T cell metabolism to improve immunity. J. Clin. Invest., 132 (1). ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

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Abstract

Vaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens are often based on the efficiency of the acute immune response, and not necessarily on the generation of memory cells, in part because the mechanisms underlying the development of efficient immune memory remain incompletely understood. This Review describes recent advances in defining memory T cell metabolism and how metabolism of these cells might be altered in patients affected by mitochondrial diseases or metabolic syndrome, who show higher susceptibility to recurrent infections and higher rates of vaccine failure. It discusses how this new understanding could add to the way we think about immunologic memory, vaccine development, and cancer immunotherapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Corrado, Mauro UNSPECIFIED orcid.org/0000-0002-0617-3274 UNSPECIFIED Pearce, Erika L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673156
DOI:	10.1172/JCI148546
Journal or Publication Title:	J. Clin. Invest.
Volume:	132
Number:	1
Date:	2022
Publisher:	AMER SOC CLINICAL INVESTIGATION INC
Place of Publication:	ANN ARBOR
ISSN:	1558-8238
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GLYCOLYTIC METABOLISM; B-CELL; MITOCHONDRIAL BIOGENESIS; IL-2 RECEPTOR; INBORN-ERRORS; EFFECTOR; RESPONSES; CD28; VACCINE; LEPTIN Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67315