Universität zu Köln

Drinhaus, Hendrik ORCID: 0000-0001-8435-2246, Schroeder, Daniel C., Hunzelmann, Nicolas, Herff, Holger, Annecke, Thorsten, Boettiger, Bernd W. and Wetsch, Wolfgang A. ORCID: 0000-0001-5800-6665 (2022). Shedding of the Endothelial Glycocalyx Independent of Systemic Tryptase Release during Oncologic Oral Surgery: An Observational Study. J. Clin. Med., 11 (19). BASEL: MDPI. ISSN 2077-0383

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Abstract

The endothelial glycocalyx and endothelial surface layer are crucial for several functions of the vasculature. Damage to the glycocalyx (shedding) occurs during diverse clinical conditions, including major surgery. Mast cell tryptase has been proposed as one possible sheddase. During oncologic oral surgery, glycocalyx shedding could be detrimental due to loss of vascular barrier function and consequent oedema in the musculocutaneous flap graft. Concentrations of the glycocalyx components heparan sulphate and syndecan-1, as well as of tryptase in blood serum before and after surgery, were measured in 16 patients undergoing oncologic oral surgery. Secondary measures were the concentrations of these substances on postoperative days 1 and 2. Heparan sulphate rose from 692 (median, interquartile range: 535-845) to 810 (638-963) ng/mL during surgery. Syndecan-1 increased from 35 (22-77) ng/mL to 138 (71-192) ng/mL. Tryptase remained virtually unchanged with 4.2 (3-5.6) before and 4.2 (2.5-5.5) ng/mL after surgery. Concentrations of heparan sulphate and syndecan-1 in serum increased during surgery, indicating glycocalyx shedding. Tryptase concentration remained equal, suggesting other sheddases than systemic tryptase release to be responsible for damage to the glycocalyx. Investigating strategies to protect the glycocalyx during oncologic oral surgery might hold potential to improve flap viability and patient outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Drinhaus, Hendrik UNSPECIFIED orcid.org/0000-0001-8435-2246 UNSPECIFIED Schroeder, Daniel C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunzelmann, Nicolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Herff, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Annecke, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Boettiger, Bernd W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wetsch, Wolfgang A. UNSPECIFIED orcid.org/0000-0001-5800-6665 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673253
DOI:	10.3390/jcm11195797
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	19
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEPSIS; HEAD Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67325