Universität zu Köln

Mellinghoff, Sibylle C., Stemler, Jannik, Forkl, Stefanie, Khatamzas, Elham and Classen, Annika Y. (2022). Management of infection in immunocompromised patients. Dtsch. Med. Wochenschr., 147 (13). S. 840 - 851. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413

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Abstract

The number of immunosuppressed patients continues to increase worldwide. The main reasons are the demographic development and improved long-term survival, also for patients under immunosuppression. A major cause of hospitalization and mortality among these patients are infections. Their management, including prevention and adequate treatment, plays a crucial role in survival and quality of life, but also with regard to economic factors. Infection management in immunocompromised patients faces new challenges today. Not only the increasing number, but also new groups of patients at risk and an increasingly aging and comorbid population pose problems for the treating physicians. While cancer medicine is no longer determined solely by radiotherapy and chemotherapy, new targeted substances are playing an increasingly important role. In addition, new targeted substances complicate adequate infection prophylaxis due to potential interactions. The worldwide increase in antibiotic-resistant pathogens complicates treatment of bacterial infections, which is associated with increased mortality, especially in the immunocompromised patient population. Further, the disruption of the microbiome shows negative antibiotic-associated effects. Hence the reasonable use of anti-infectives in prophylaxis and therapy is of great importance. There are many recommendations and guidelines for clinicians regarding the management of infections in immunocompromised patients. Overlaps of infectiology, hygiene as well as hematology and oncology sometimes lead to different recommendations. This article provides an overview of the currently existing evidence and guidelines for infection management in immunosuppressed patients.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mellinghoff, Sibylle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stemler, Jannik UNSPECIFIED UNSPECIFIED UNSPECIFIED Forkl, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Khatamzas, Elham UNSPECIFIED UNSPECIFIED UNSPECIFIED Classen, Annika Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-673290
DOI:	10.1055/a-1684-6763
Journal or Publication Title:	Dtsch. Med. Wochenschr.
Volume:	147
Number:	13
Page Range:	S. 840 - 851
Date:	2022
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4413
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DISEASES WORKING PARTY; HIGH-RISK PATIENTS; GERMAN SOCIETY; HEMATOLOGIC MALIGNANCIES; PRIMARY PROPHYLAXIS; AGIHO; GUIDELINES; COMPLICATIONS; UPDATE Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67329