Universität zu Köln

Kosian, Philipp ORCID: 0000-0002-2201-1494, Hellmund, Astrid, Geipel, Annegret, Bald, Rainer, Geist, Otilia-Maria, Bockenhoff, Paul, Jimenez-Cruz, Jorge, Deja, Maria, Strizek, Brigitte, Berg, Christoph and Gembruch, Ulrich ORCID: 0000-0001-8284-4669 . Intrauterine transfusion in 103 fetuses with severe anemia caused by parvovirus infection. A multicenter retrospective study. Arch. Gynecol. Obstet.. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

Full text not available from this repository.

Abstract

Purpose Evaluating procedure-related complications and perinatal outcomes after intrauterine transfusion (IUT) before or after 20(+0) weeks of gestation in fetuses with severe anemia due to intrauterine human parvovirus B19 infection. Methods A retrospective study investigating fetuses requiring IUT for fetal Parvo B19 infection in two tertiary referral centers between December 2002 and December 2021. Procedure-related complications, intrauterine fetal death (IUFD), and perinatal outcome were correlated to gestational age (GA) at first IUT, the presence of hydrops and fetal blood sampling results. Results A total of 186 IUTs were performed in 103 fetuses. The median GA at first IUT was 19(+3) (13(+0)-31(+4)) weeks of gestation. IUFD occurred in 16/103 fetuses (15.5%). Overall survival was 84.5% (87/103). Hydrops (p = 0.001), lower mean hemoglobin at first IUT (p = 0.001) and low platelets (p = 0.002) were strongly associated with IUFD. There was no difference observed in fetuses transfused before or after 20(+0) weeks of gestation. Conclusion IUT is a successful treatment option in fetuses affected by severe anemia due to parvovirus B19 infection in specialized centers. In experienced hands, IUT before 20 weeks is not related to worse perinatal outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kosian, Philipp UNSPECIFIED orcid.org/0000-0002-2201-1494 UNSPECIFIED Hellmund, Astrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED Bald, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Geist, Otilia-Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Bockenhoff, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Jimenez-Cruz, Jorge UNSPECIFIED UNSPECIFIED UNSPECIFIED Deja, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Strizek, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, Ulrich UNSPECIFIED orcid.org/0000-0001-8284-4669 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674102
DOI:	10.1007/s00404-022-06712-z
Journal or Publication Title:	Arch. Gynecol. Obstet.
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language B19 INFECTION; FETAL ANEMIA; DOPPLER ULTRASONOGRAPHY; NONINVASIVE DIAGNOSIS; EXCHANGE-TRANSFUSION; HYDROPIC FETUSES; MANAGEMENT; PREGNANCY; THROMBOCYTOPENIA; COMPLICATIONS Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67410