Universität zu Köln

Herold, Natalie ORCID: 0000-0002-4493-5807, Hellmich, Martin, Lichtenheldt, Frank, Ataseven, Beyhan ORCID: 0000-0002-2823-7590, Hillebrand, Vanessa, Wappenschmidt, Barbara, Schmutzler, Rita Katharina and Rhiem, Kerstin (2022). Satisfaction and Quality of Life of Healthy and Unilateral Diseased BRCA1/2 Pathogenic Variant Carriers after Risk-Reducing Mastectomy and Reconstruction Using the BREAST-Q Questionnaire. Genes, 13 (8). BASEL: MDPI. ISSN 2073-4425

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Abstract

Risk-reducing mastectomy (RRM) is the most efficient form of breast cancer (BC) risk reduction in BRCA1/2 pathogenic variant (pV) carriers. However, this intervention in physical integrity is associated with significant morbidity. We assessed long-term perception of satisfaction and health-related quality of life (QoL) after bilateral RRM and reconstruction using the validated BREAST-Q. We searched the prospective database of the Center for Hereditary Breast and Ovarian Cancer Cologne for previvors and survivors who underwent bilateral RRM from 1994 to 2015 and evaluated the results of their BREAST-Q scores. The study enrolled 43 previvors and 90 survivors after a mean follow-up of 46.3 +/- 45.3 months after RRM. Satisfaction and QoL were independent of the technique of RRM or type of reconstruction but depended on the time of RRM. Compared to survivors, previvors had significantly higher mean satisfaction scores in their psychosocial, sexual, and physical well-being (chest) in both modules. Among previvors and survivors, higher psychological well-being correlated with a higher satisfaction with information and higher satisfaction with outcome. As psychological well-being correlated with satisfaction with information and outcome, we developed decision aids to improve shared decision making and long-term satisfaction with the decision and the postoperative outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herold, Natalie UNSPECIFIED orcid.org/0000-0002-4493-5807 UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenheldt, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Ataseven, Beyhan UNSPECIFIED orcid.org/0000-0002-2823-7590 UNSPECIFIED Hillebrand, Vanessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Wappenschmidt, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674262
DOI:	10.3390/genes13081357
Journal or Publication Title:	Genes
Volume:	13
Number:	8
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4425
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BILATERAL PROPHYLACTIC MASTECTOMY; MUTATION CARRIERS; DECISION-MAKING; CANCER; WOMEN; OUTCOMES; SENSITIVITY; SURVIVAL; SURGERY; OVARIAN Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67426