Universität zu Köln

Muller, Marion, Bischof, Cornelius, Kapries, Torben, Wollnitza, Sophie, Liechty, Chiara, Geissen, Simon, Schubert, Torben, Opacic, Dragan, Gercek, Muhammed, Fortmeier, Vera, Dumitrescu, Daniel, Schlomann, Uwe, Sydykov, Akylbek, Petrovic, Aleksandar, Gnatzy-Feik, Leoni, Milting, Hendrik, Schermuly, Ralph T., Friedrichs, Kai, Rudolph, Volker and Klinke, Anna (2022). Right Heart Failure in Mice Upon Pressure Overload Is Promoted by Mitochondrial Oxidative Stress. JACC-Basic Transl. Sci., 7 (7). S. 658 - 678. NEW YORK: ELSEVIER SCIENCE INC. ISSN 2452-302X

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Abstract

We sought to unravel pathomechanisms of the transition of maladaptive right ventricular (RV) remodeling to right heart failure (RHF) upon pressure overload. Exposure of C57BL/6J and C57BL/6N mice to pulmonary artery banding disclosed a tight relation of structural remodeling with afterload, but a dissociation from RV systolic function. Reduced release of mitochondrial reactive oxygen species in C57BL/6J mice prevented the development of RHF. In patients with left heart failure, increased oxidative damage in RV sections was asso-ciated with severely impaired RV function. In conclusion, reactive oxygen species are involved in the transition of maladaptive RV remodeling to RHF. (J Am Coll Cardiol Basic Trans Science 2022;7:658???677) ?? 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Muller, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Bischof, Cornelius UNSPECIFIED UNSPECIFIED UNSPECIFIED Kapries, Torben UNSPECIFIED UNSPECIFIED UNSPECIFIED Wollnitza, Sophie UNSPECIFIED UNSPECIFIED UNSPECIFIED Liechty, Chiara UNSPECIFIED UNSPECIFIED UNSPECIFIED Geissen, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert, Torben UNSPECIFIED UNSPECIFIED UNSPECIFIED Opacic, Dragan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gercek, Muhammed UNSPECIFIED UNSPECIFIED UNSPECIFIED Fortmeier, Vera UNSPECIFIED UNSPECIFIED UNSPECIFIED Dumitrescu, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlomann, Uwe UNSPECIFIED UNSPECIFIED UNSPECIFIED Sydykov, Akylbek UNSPECIFIED UNSPECIFIED UNSPECIFIED Petrovic, Aleksandar UNSPECIFIED UNSPECIFIED UNSPECIFIED Gnatzy-Feik, Leoni UNSPECIFIED UNSPECIFIED UNSPECIFIED Milting, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Schermuly, Ralph T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrichs, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Rudolph, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Klinke, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674274
DOI:	10.1016/j.jacbts.2022.02.018
Journal or Publication Title:	JACC-Basic Transl. Sci.
Volume:	7
Number:	7
Page Range:	S. 658 - 678
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	2452-302X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RIGHT-VENTRICULAR HYPERTROPHY; TRANSHYDROGENASE; MECHANISMS; APOPTOSIS; DEATH; LOAD Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67427