Universität zu Köln

Gaca, Piotr Jakub, Lewandowicz, Michael, Lipczynska-Lewandowska, Malgorzata, Simon, Michael, Matos, Philomena A. Wawer, Doulis, Alexandros, Rokohl, Alexander C. and Heindl, Ludwig M. (2022). Fetal Development of the Orbit. Klinische Monatsblat. Augenheilkunde, 239 (1). S. 27 - 37. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Human prenatal development is divided into an embryonic period and a fetal period. Intense organogenetic activity occurs in the embryonic period of prenatal life, while the fetal period is marked by less intense changes. Knowledge of the embryology of the orbit not only allows insights into how normal variations in the orbital structure arise but also provides an understanding of how congenital deformities occur when normal orbital development goes awry. In order to explore our understanding of the developmental anatomy of the orbit during the fetal period of prenatal life, the authors have summarized the major milestones in orbital morphogenesis, a temporally precise and morphogenetically intricate process. This process can be considered as an anatomic series of complex, well-orchestrated changes in morphology as well as a series of complex biochemical and molecular events that coordinate and control the anatomic development. Identifying and linking signaling pathways and regulatory genes linked with normal orbital morphogenesis is a crucial step to offer patients with chronic or incurable orbital diseases effective treatment options in the future.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gaca, Piotr Jakub UNSPECIFIED UNSPECIFIED UNSPECIFIED Lewandowicz, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lipczynska-Lewandowska, Malgorzata UNSPECIFIED UNSPECIFIED UNSPECIFIED Simon, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Matos, Philomena A. Wawer UNSPECIFIED UNSPECIFIED UNSPECIFIED Doulis, Alexandros UNSPECIFIED UNSPECIFIED UNSPECIFIED Rokohl, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-674493
DOI:	10.1055/a-1717-1959
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	239
Number:	1
Page Range:	S. 27 - 37
Date:	2022
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH; MORPHOGENESIS; APPEARANCE; EMBRYOLOGY; OCULOMOTOR; TISSUE; MUSCLE; EYE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67449