Universität zu Köln

Scurt, Florian G., Ernst, Angela ORCID: 0000-0003-2375-1889, Wassermann, Tamara, Hammoud, Ben, Mertens, Peter R., Schwarz, Anke, Becker, Jan U. and Chatzikyrkou, Christos (2023). Short-term outcomes after transplantation of deceased donor kidneys with acute kidney injury: a retrospective analysis of a multicenter cohort of marginal donor kidneys with post-explantation biopsies. Int. Urol. Nephrol., 55 (1). S. 115 - 128. DORDRECHT: SPRINGER. ISSN 1573-2584

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Abstract

Background Deceased donor kidneys with acute kidney injury (AKI) are often discarded because of concerns about inferior transplant outcomes. A means of grading the quality of such kidneys is the performance of procurement biopsies. Methods This is a retrospective study of 221 brain death donors with marginal kidneys transplanted in 223 recipients in Germany. Marginal kidneys were defined as kidneys with procurement biopsies done exceptionally to assess suitability for transplantation in otherwise potentially discarded organs. The impact of deceased donor AKI on patient survival and death-censored graft survival at 1, 3 and 5 years and graft function at 1 and 3 years after transplantation was investigated. Results Recipients of kidneys with stage 3 AKI had a greater incidence of delayed graft function [DGF; ORStage 1: 1.435 (95% CI 0.438-0.702), ORStage 2: 2.463 (95% CI 0.656-9.245), ORStage 3: 4.784 (95% CI 1.421-16.101)] but a similar graft and patient survival compared to recipients of donors without AKI and with AKI stage 1 and 2 as well. The coexistence of recipient DGF and donor AKI was associated with the lowest graft survival and function rates. Conclusion The transplantation of deceased donor marginal kidneys with AKI confers a higher risk for DGF but is associated with acceptable graft and patient outcomes, which do not differ in comparison with marginal donor kidneys without AKI. Graft prognosis is especially poor if donor AKI and recipient DGF concur. Donor AKI was a risk factor independent of the histological lesions of procurement biopsies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scurt, Florian G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Angela UNSPECIFIED orcid.org/0000-0003-2375-1889 UNSPECIFIED Wassermann, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammoud, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Mertens, Peter R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Jan U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatzikyrkou, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675147
DOI:	10.1007/s11255-022-03277-3
Journal or Publication Title:	Int. Urol. Nephrol.
Volume:	55
Number:	1
Page Range:	S. 115 - 128
Date:	2023
Publisher:	SPRINGER
Place of Publication:	DORDRECHT
ISSN:	1573-2584
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASSOCIATIONS Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67514