Universität zu Köln

Loehrer, Philipp A., Weber, Immo, Oehrn, Carina R., Nettersheim, Felix S., Dafsari, Haidar S. ORCID: 0000-0001-8849-4233, Knake, Susanne, Tittgemeyer, Marc, Timmermann, Lars and Belke, Marcus (2022). Microstructural alterations predict impaired bimanual control in Parkinson's disease. Brain Commun., 4 (3). OXFORD: OXFORD UNIV PRESS. ISSN 2632-1297

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Abstract

Bimanual coordination is impaired in Parkinson's disease affecting patients' ability to perform activities of daily living and to maintain independence. Conveyance of information between cortical and subcortical areas is essential for bimanual coordination and relies on the integrity of cerebral microstructure. As pathological deposition of alpha-synuclein compromises microstructure in Parkinson's disease, we investigated the relationship between microstructural integrity and bimanual coordination using diffusion-weighted MRI in 23 patients with Parkinson's disease (mean age +/- standard deviation: 56.0 +/- 6.45 years; 8 female) and 26 older adults (mean age +/- standard deviation: 58.5 +/- 5.52 years). Whole-brain analysis revealed specific microstructural alterations between patients and healthy controls matched for age, sex, handedness, and cognitive status congruent with the literature and known Parkinson's disease pathology. A general linear model revealed distinct microstructural alterations associated with poor bimanual coordination in Parkinson's disease, corrected for multiple comparisons using a permutation-based approach. Integrating known functional topography, we conclude that distinct changes in microstructure cause an impediment of structures involved in attention, working memory, executive function, motor planning, motor control, and visual processing contributing to impaired bimanual coordination in Parkinson's disease. Loehrer et al. investigate the relationship between microstructural integrity and bimanual coordination in Parkinson's disease and healthy controls employing diffusion-weighted imaging. Whole-brain analysis revealed that alterations in structures involved in attention, working memory, executive function, motor planning, motor control and visual processing predicted impaired bimanual coordination in Parkinson's disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loehrer, Philipp A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Immo UNSPECIFIED UNSPECIFIED UNSPECIFIED Oehrn, Carina R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nettersheim, Felix S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dafsari, Haidar S. UNSPECIFIED orcid.org/0000-0001-8849-4233 UNSPECIFIED Knake, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Belke, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675174
DOI:	10.1093/braincomms/fcac137
Journal or Publication Title:	Brain Commun.
Volume:	4
Number:	3
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2632-1297
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURITE ORIENTATION DISPERSION; GEOMETRICALLY ACCURATE; DIFFUSION; ABNORMALITIES; DYSFUNCTION; ROBUST; MRI; SEGMENTATION; CONNECTIVITY; COORDINATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67517