Universität zu Köln

Banwinkler, Magdalena ORCID: 0000-0001-7086-9973, Dzialas, Verena, Hoenig, Merle C. and van Eimeren, Thilo (2022). Gray Matter Volume Loss in Proposed Brain-First and Body-First Parkinson's Disease Subtypes. Mov. Disord., 37 (10). S. 2066 - 2075. HOBOKEN: WILEY. ISSN 1531-8257

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Abstract

Background: alpha-Synuclein pathology is associated with neuronal degeneration in Parkinson's disease (PD) and considered to sequentially spread across the brain (Braak stages). According to a new hypothesis of distinct alpha-synuclein spreading directions based on the initial site of pathology, the brain-first spreading subtype would be associated with a more asymmetric cerebral and nigrostriatal pathology than the body-first subtype. Objective: Here, we tested if proposed markers of brain-first PD (ie, higher dopamine transporter [DaT] asymmetry; absence of rapid eye movement sleep behavior disorder [RBD]) are associated with a greater or more asymmetric reduction in gray matter volume (GMV) in comparison to body-first PD. Methods: Data of 255 de novo PD patients and 110 healthy controls (HCs) were retrieved from the Parkinson's Progression Markers Initiative. Structural magnetic resonance images were preprocessed, and GMVs and their hemispherical asymmetry were obtained for each of the neuropathologically defined Braak stages. Group and correlation comparisons were performed to assess differences in GMV and GMV asymmetry between PD subtypes. Results: PD patients demonstrated significantly smaller bilateral GMVs compared to HCs, in a pattern denoting stage-dependent disease-related brain atrophy. However, the degree of putaminal DaT asymmetry was not associated with reduced GMV or higher GMV asymmetry. Furthermore, RBD-negative and RBD-positive patients did not demonstrate a significant difference in GMV or GMV asymmetry. Conclusions: Our findings suggest that putative brain-first and body-first patients do not present diverging brain atrophy patterns. Although certainly not disproving the brain-first/body-first spreading hypothesis, this study fails to provide evidence in support of it. (C) 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Banwinkler, Magdalena UNSPECIFIED orcid.org/0000-0001-7086-9973 UNSPECIFIED Dzialas, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoenig, Merle C. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Eimeren, Thilo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-675622
DOI:	10.1002/mds.29172
Journal or Publication Title:	Mov. Disord.
Volume:	37
Number:	10
Page Range:	S. 2066 - 2075
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1531-8257
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SLEEP BEHAVIOR DISORDER; SCREENING QUESTIONNAIRE; ALPHA-SYNUCLEIN; EARLY-STAGE; SUBSTANTIA-NIGRA; ATROPHY; ASYMMETRY; PATHOLOGY; AMYGDALA; LEWY Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67562