Universität zu Köln

Back, Sarah N., Schmitz, Marius ORCID: 0000-0002-2462-1587, Koenig, Julian ORCID: 0000-0003-1009-9625, Zettl, Max, Kleindienst, Nikolaus, Herpertz, Sabine C. and Bertsch, Katja ORCID: 0000-0001-9177-9010 (2022). Reduced vagal activity in borderline personality disorder is unaffected by intranasal oxytocin administration, but predicted by the interaction between childhood trauma and attachment insecurity. J. Neural Transm., 129 (4). S. 409 - 420. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

Individuals with borderline personality disorder (BPD) show self-regulatory deficits, associated with reduced heart-rate variability (HRV). However, results on reduced HRV in BPD remain heterogeneous, thus encouraging the search for developmental constructs explaining this heterogeneity. The present study first examined predictors of reduced resting-state HRV in BPD, namely the interaction between self-reported adult attachment insecurity and childhood trauma. Second, we investigated if alterations in resting-state HRV are modified by intranasal oxytocin administration, as oxytocin may enhance HRV and is implicated in the interaction between childhood trauma and disturbed attachment for the pathogenesis of BPD. In a randomized, placebo-controlled trial, 53 unmedicated women with BPD and 60 healthy controls (HC) self-administered either 24 I.U. of oxytocin or placebo and underwent a 4-min electrocardiogram. Our results replicate significantly reduced HRV in women with BPD, explained up to 16% by variations in childhood trauma and attachment insecurity. At high levels of acute attachment insecurity, higher levels of childhood trauma significantly predicted reduced HRV in BPD. However, our results do not support a significant effect of oxytocin on mean HRV, and no interaction effect emerged including childhood trauma and attachment insecurity. Our findings highlight a complex interaction between reduced vagal activity and developmental factors in BPD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Back, Sarah N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmitz, Marius UNSPECIFIED orcid.org/0000-0002-2462-1587 UNSPECIFIED Koenig, Julian UNSPECIFIED orcid.org/0000-0003-1009-9625 UNSPECIFIED Zettl, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleindienst, Nikolaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Herpertz, Sabine C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertsch, Katja UNSPECIFIED orcid.org/0000-0001-9177-9010 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676273
DOI:	10.1007/s00702-022-02482-9
Journal or Publication Title:	J. Neural Transm.
Volume:	129
Number:	4
Page Range:	S. 409 - 420
Date:	2022
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEART-RATE-VARIABILITY; POSTTRAUMATIC-STRESS-DISORDER; EMOTION REGULATION; CARDIAC-FUNCTION; FEMALE-PATIENTS; REACTIVITY; WOMEN; PERSPECTIVE; EXPERIENCES; ADVERSITY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67627