Universität zu Köln

Borggrefe, Jan, Gebest, Max Philipp, Hauger, Myriam, Ruess, Daniel, Mpotsaris, Anastasios, Kabbasch, Christoph, Pennig, Lenhard ORCID: 0000-0002-6606-9313, Laukamp, Kai Roman, Goertz, Lukas, Kroeger, Jan Robert ORCID: 0000-0003-1218-7610 and Doerner, Jonas (2022). Differentiation of Intracerebral Tumor Entities with Quantitative Contrast Attenuation and Iodine Mapping in Dual-Layer Computed Tomography. Diagnostics, 12 (10). BASEL: MDPI. ISSN 2075-4418

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Abstract

Purpose: To investigate if quantitative contrast enhancement and iodine mapping of common brain tumor (BT) entities may correctly differentiate between tumor etiologies in standardized stereotactic CT protocols. Material and Methods: A retrospective monocentric study of 139 consecutive standardized dual-layer dual-energy CT (dlDECT) scans conducted prior to the stereotactic needle biopsy of untreated primary brain tumor lesions. Attenuation of contrast-enhancing BT was derived from polyenergetic images as well as spectral iodine density maps (IDM) and their contrast-to-noise-ratios (CNR) were determined using ROI measures in contrast-enhancing BT and healthy contralateral white matter. The measures were correlated to histopathology regarding tumor entity, isocitrate dehydrogenase (IDH) and MGMT mutation status. Results: The cohort included 52 female and 76 male patients, mean age of 59.4 (+/- 17.1) years. Brain lymphomas showed the highest attenuation (IDM CNR 3.28 +/- 1,23), significantly higher than glioblastoma (2.37 +/- 1.55, p < 0.005) and metastases (1.95 +/- 1.14, p < 0.02), while the differences between glioblastomas and metastases were not significant. These strongly enhancing lesions differed from oligodendroglioma and astrocytoma (Grade II and III) that showed IDM CNR in the range of 1.22-1.27 (+/- 0.45-0.82). Conventional attenuation measurements in DLCT data performed equally or slightly superior to iodine density measurements. Conclusion: Quantitative attenuation and iodine density measurements of contrast-enhancing brain tumors are feasible imaging biomarkers for the discrimination of cerebral tumor lesions but not specifically for single tumor entities. CNR based on simple HU measurements performed equally or slightly superior to iodine quantification.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Borggrefe, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Gebest, Max Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Hauger, Myriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruess, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Mpotsaris, Anastasios UNSPECIFIED UNSPECIFIED UNSPECIFIED Kabbasch, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Pennig, Lenhard UNSPECIFIED orcid.org/0000-0002-6606-9313 UNSPECIFIED Laukamp, Kai Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Goertz, Lukas UNSPECIFIED UNSPECIFIED UNSPECIFIED Kroeger, Jan Robert UNSPECIFIED orcid.org/0000-0003-1218-7610 UNSPECIFIED Doerner, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-676536
DOI:	10.3390/diagnostics12102494
Journal or Publication Title:	Diagnostics
Volume:	12
Number:	10
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2075-4418
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CT; BRAIN; OXYGENATION; PERFUSION; GLIOMAS Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67653