Strubl, Sebastian, Oehm, Simon ORCID: 0000-0003-4657-6091, Torres, Jacob A., Grundmann, Franziska, Haratani, Jazmine, Decker, Morgan, Vuong, Sabrina, Bhandal, Amrit Kaur, Methot, Nils, Haynie-Cion, Rhianna, Meyer, Franziska, Siedek, Florian, Korst, Uwe, Muller, Roman-Ulrich and Weimbs, Thomas (2022). Ketogenic dietary interventions in autosomal dominant polycystic kidney disease-a retrospective case series study: first insights into feasibility, safety and effects. Clin. Kidney J., 15 (6). S. 1079 - 1093. OXFORD: OXFORD UNIV PRESS. ISSN 2048-8513

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Abstract

Background Our laboratory published the first evidence that nutritional ketosis, induced by a ketogenic diet (KD) or time-restricted diet (TRD), ameliorates disease progression in polycystic kidney disease (PKD) animal models. We reasoned that, due to their frequent use for numerous health benefits, some autosomal dominant PKD (ADPKD) patients may already have had experience with ketogenic dietary interventions (KDIs). This retrospective case series study is designed to collect the first real-life observations of ADPKD patients about safety, feasibility and possible benefits of KDIs in ADPKD as part of a translational project pipeline. Methods Patients with ADPKD who had already used KDIs were recruited to retrospectively collect observational and medical data about beneficial or adverse effects and the feasibility and safety of KDIs in questionnaire-based interviews. Results A total of 131 ADPKD patients took part in this study. About 74 executed a KD and 52 a TRD for 6 months on average. A total of 86% of participants reported that KDIs had improved their overall health, 67% described improvements in ADPKD-associated health issues, 90% observed significant weight loss, 64% of participants with hypertension reported improvements in blood pressure, 66% noticed adverse effects that are frequently observed with KDIs, 22 participants reported safety concerns like hyperlipidemia, 45 participants reported slight improvements in estimated glomerular filtration rate and 92% experienced KDIs as feasible while 53% reported breaks during their diet. Conclusions Our preliminary data indicate that KDIs may be safe, feasible and potentially beneficial for ADPKD patients, highlighting that prospective clinical trials are warranted to confirm these results in a controlled setting and elucidate the impact of KDIs specifically on kidney function and cyst progression.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Strubl, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oehm, SimonUNSPECIFIEDorcid.org/0000-0003-4657-6091UNSPECIFIED
Torres, Jacob A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grundmann, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haratani, JazmineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Decker, MorganUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vuong, SabrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bhandal, Amrit KaurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Methot, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haynie-Cion, RhiannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siedek, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Korst, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, Roman-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weimbs, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-677385
DOI: 10.1093/ckj/sfab162
Journal or Publication Title: Clin. Kidney J.
Volume: 15
Number: 6
Page Range: S. 1079 - 1093
Date: 2022
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 2048-8513
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LOW-CARBOHYDRATE DIET; ORTHOLOGOUS MOUSE MODEL; WEIGHT-LOSS; LOW-FAT; RISK-FACTORS; RENAL-FUNCTION; KETONE-BODIES; PROGRESSION; OVERWEIGHT; TOLVAPTANMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67738

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