Universität zu Köln

Reimer, N., Hafke, R., Wrensch, M., Horst, P., Bloch, W., Hahn, T., Kirchhoff, A., Kluck, K-L, Stein, J. and Baumann, F. T. (2022). Influence of a 12-month supervised, intensive resistance, aerobic and impact exercise intervention on muscle strength in prostate cancer patients undergoing anti-hormone therapy: Study protocol for the randomized, controlled Burgdorf study. Contemp. Clin. Trials, 114. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1559-2030

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Abstract

Introduction: Reduced testosterone levels due to androgen deprivation therapy (ADT) in prostate cancer patients cause common side effects, such as reduced muscle strength and bone density, increased fat mass, sexual dysfunction and fatigue. Short-term exercise during ADT has proven to be safe and effective in exhibiting a positive impact on body composition, sexual dysfunction and fatigue. However, there are only three randomized controlled trials that investigate one-year supervised impact exercise interventions, none of which examined follow-up effects after the intervention. Therefore, this study will conduct a one-year impact exercise intervention and assess follow-up effects up to one year later. Material and methods: The aim of the randomized, controlled Burgdorf study is to assess the effects of a supervised 12- month intensive multimodal exercise intervention in comparison to a moderate aerobic exercise intervention, on muscle strength in prostate cancer patients receiving ADT. Additionally, quality of life, fatigue, body composition, erectile dysfunction, bone pain, physical activity level, endurance capacity, body-mass-index, waist and hip circumference and prostate-specific antigen- and testosterone levels will be assessed up to one year later. Discussion: The Burgdorf study is the first study to conduct two different one-year supervised exercise interventions, and follow-up with patients for up to one year after the intervention. Results could provide important insights into the long-term effects of interventions on those parameters negatively affected by ADT, which could specify or newly establish care structures. Trial registration: German Clinical Trials Register, DRKS00009975. Registered 2016-02-09, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00009975

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Reimer, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hafke, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wrensch, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Horst, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bloch, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hahn, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kirchhoff, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kluck, K-L UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumann, F. T. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678526
DOI:	10.1016/j.cct.2022.106685
Journal or Publication Title:	Contemp. Clin. Trials
Volume:	114
Date:	2022
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1559-2030
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANDROGEN DEPRIVATION THERAPY; BIOELECTRICAL-IMPEDANCE ANALYSIS; QUALITY-OF-LIFE; MEN; INSTRUMENT; FATIGUE; PROGRAM; MASS; FAT Multiple languages Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67852