Universität zu Köln

Hanssen, Ruth ORCID: 0000-0002-7283-9302, Thanarajah, Sharmili E., Tittgemeyer, Marc and Bruening, Jens C. (2022). Obesity - A Matter of Motivation? Exp. Clin. Endocrinol. Diabet., 130 (5). S. 290 - 296. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3646

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Abstract

Excessive food intake and reduced physical activity have long been established as primary causes of obesity. However, the underlying mechanisms causing this unhealthy behavior characterized by heightened motivation for food but not for physical effort are unclear. Despite the common unjustified stigmatization that obesity is a result of laziness and lack of discipline, it is becoming increasingly clear that high-fat diet feeding and obesity cause alterations in brain circuits that are critical for the control of motivational behavior. In this mini-review, we provide a comprehensive overview of incentive motivation, its neural encoding in the dopaminergic mesolimbic system as well as its metabolic modulation with a focus on derangements of incentive motivation in obesity. We further discuss the emerging field of metabolic interventions to counteract motivational deficits and their potential clinical implications.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hanssen, Ruth UNSPECIFIED orcid.org/0000-0002-7283-9302 UNSPECIFIED Thanarajah, Sharmili E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tittgemeyer, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruening, Jens C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-678722
DOI:	10.1055/a-1749-4852
Journal or Publication Title:	Exp. Clin. Endocrinol. Diabet.
Volume:	130
Number:	5
Page Range:	S. 290 - 296
Date:	2022
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3646
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language D-2/3 RECEPTOR AVAILABILITY; MESOLIMBIC DOPAMINE SYSTEM; BODY-MASS INDEX; FOOD-INTAKE; LONG-TERM; LEPTIN RECEPTOR; ENERGY-INTAKE; REWARD; INSULIN; INCREASES Multiple languages Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67872