Universität zu Köln

Kindler, Jochen ORCID: 0000-0002-9034-2770, Koenig, Julian, Lerch, Stefan, van der Venne, Patrice, Resch, Franz and Kaess, Michael ORCID: 0000-0003-0031-7764 (2022). Increased immunological markers in female adolescents with non-suicidal self-injury. J. Affect. Disord., 318. S. 191 - 196. AMSTERDAM: ELSEVIER. ISSN 1573-2517

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Abstract

Background: Nonsuicidal self-injury (NSSI) is a prevalent health problem among adolescents and commonly associated with psychological stressors such as childhood maltreatment and comorbid psychiatric disorders (e.g., depression). There is evidence that alterations of immunological markers may occur in the context of both environmental stress and psychopathological development. Method: Here, we investigated differences in plasma/serum leukocytes, cortisol, c-reactive protein and interleukin-6 in a large sample of female adolescents with NSSI (n = 155) and healthy controls (HC, n = 42). Further, we assessed correlations between inflammatory markers, depression severity and the severity of childhood maltreatment. Results: The absolute number of leukocytes and the leukocyte/cortisol ratio (adjusted for body mass index and smoking) were significantly higher in NSSI as compared to HC, whereas interleukin-6 and CRP levels did not differ significantly between groups. Childhood maltreatment scores were significantly correlated with the leukocyte/cortisol ratio and depression severity was significantly correlated with both, absolute leukocyte numbers and the leukocyte/cortisol ratio. Conclusions: Our results suggest that an immune activation can be detected in female adolescents with NSSI. Depression and childhood maltreatment, which are commonly reported in NSSI, may potentially underlie immune activation and partially explain group differences.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kindler, Jochen UNSPECIFIED orcid.org/0000-0002-9034-2770 UNSPECIFIED Koenig, Julian UNSPECIFIED UNSPECIFIED UNSPECIFIED Lerch, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Venne, Patrice UNSPECIFIED UNSPECIFIED UNSPECIFIED Resch, Franz UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaess, Michael UNSPECIFIED orcid.org/0000-0003-0031-7764 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679221
DOI:	10.1016/j.jad.2022.08.125
Journal or Publication Title:	J. Affect. Disord.
Volume:	318
Page Range:	S. 191 - 196
Date:	2022
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1573-2517
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFLAMMATION; METAANALYSIS; INTERVIEW; STRESS Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67922