Universität zu Köln

Scurt, Florian G., Ernst, Angela, Hammoud, Ben, Wassermann, Tamara, Mertens, Peter R., Schwarz, Anke, Becker, Jan U. and Chatzikyrkou, Christos (2022). Effect of on outcome after transplantation of marginal donor kidneys. Nephrology, 27 (12). S. 973 - 983. HOBOKEN: WILEY. ISSN 1440-1797

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Abstract

Introduction Predicting outcome after transplantation of marginal kidneys is a challenging task. Donor creatinine or estimated glomerular filtration rate (eGFR) are integral components of the respective risk scores. However, there is uncertainty on which of their values obtained successively during procurement is the most suitable. Material and methods This is a retrospective study of 221 adult brain death donors with marginal kidneys, transplanted in 223 recipients. We applied logistic regression analysis to investigate the association between initial (at hospital admission), nadir (lowest), zenith (highest) and terminal (at recovery) donor eGFR with primary non-function (PNF), delayed graft function (DGF), 3- and 12-month graft function and 1- and 3-year patient- and death-censored graft survival. Results In the multivariate analysis, admission, terminal, and the lowest donor eGFR could most accurately predict DGF. The respective ORs [95% CI] were: 0.875 [0.771-0.993], 0.818 [95% CI: 0.726-0.922] and 0.793 [0.689-0.900]. Although not being significant for DGF (OR 0.931 [95% CI: 0.817-1.106]), the highest eGFR was the best predictor of 3-month graft function (adjusted b coefficient 1.161 [95% CI: 0.355-1.968]). Analysis of primary nonfunction showed that determination of initial and the highest eGFR proved to be the best predictors. The respective ORs [95% CI] were: 0.804 [0.667-0.968] and 0.750 [0.611-0.919]. There were no differences in the risk associations of each of the four eGFR recordings with patient- and graft survival. Conclusion The various eGFR recordings determined during the procurement process of marginal donors can predict PNF, DGF and 3- and 12-month graft function. Regarding short-term patient- and graft survival, there appears to be impacted by recipient factors rather than donor kidney function.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Scurt, Florian G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ernst, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Hammoud, Ben UNSPECIFIED UNSPECIFIED UNSPECIFIED Wassermann, Tamara UNSPECIFIED UNSPECIFIED UNSPECIFIED Mertens, Peter R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarz, Anke UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, Jan U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatzikyrkou, Christos UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679384
DOI:	10.1111/nep.14108
Journal or Publication Title:	Nephrology
Volume:	27
Number:	12
Page Range:	S. 973 - 983
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1440-1797
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DIALYSIS; PERFORMANCE; RECIPIENTS; CREATININE; SURVIVAL; BIOPSIES Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67938