Universität zu Köln

Lapin, Dmitry ORCID: 0000-0001-9591-3950, Johanndrees, Oliver ORCID: 0000-0001-6659-3951, Wu, Zhongshou ORCID: 0000-0001-6687-1675, Li, Xin ORCID: 0000-0002-6354-2021 and Parker, Jane E. (2022). Molecular innovations in plant TIR-based immunity signaling. Plant Cell, 34 (5). S. 1479 - 1497. CARY: OXFORD UNIV PRESS INC. ISSN 1532-298X

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Abstract

A protein domain (Toll and Interleukin-1 receptor [TIR]-like) with homology to animal TIRs mediates immune signaling in prokaryotes and eukaryotes. Here, we present an overview of TIR evolution and the molecular versatility of TIR domains in different protein architectures for host protection against microbial attack. Plant TIR-based signaling emerges as being central to the potentiation and effectiveness of host defenses triggered by intracellular and cell-surface immune receptors. Equally relevant for plant fitness are mechanisms that limit potent TIR signaling in healthy tissues but maintain preparedness for infection. We propose that seed plants evolved a specialized protein module to selectively translate TIR enzymatic activities to defense outputs, overlaying a more general function of TIRs. Plants have evolved specialized protein modules to connect TIR domain signaling to Ca2+ influx and mount effective defense responses.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lapin, Dmitry UNSPECIFIED orcid.org/0000-0001-9591-3950 UNSPECIFIED Johanndrees, Oliver UNSPECIFIED orcid.org/0000-0001-6659-3951 UNSPECIFIED Wu, Zhongshou UNSPECIFIED orcid.org/0000-0001-6687-1675 UNSPECIFIED Li, Xin UNSPECIFIED orcid.org/0000-0002-6354-2021 UNSPECIFIED Parker, Jane E. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679511
DOI:	10.1093/plcell/koac035
Journal or Publication Title:	Plant Cell
Volume:	34
Number:	5
Page Range:	S. 1479 - 1497
Date:	2022
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1532-298X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EFFECTOR-TRIGGERED IMMUNITY; NAD(+) CLEAVAGE ACTIVITY; CELL-DEATH; SALICYLIC-ACID; DISEASE RESISTANCE; STRUCTURAL BASIS; TRANSCRIPTION FACTORS; PATHOGEN EFFECTORS; MONOOXYGENASE FMO1; RECEPTOR COMPLEX Multiple languages Biochemistry & Molecular Biology; Plant Sciences; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67951