Universität zu Köln

Horneff, Gerd, Borchert, Julia, Heinrich, Ria, Kock, Simon, Klaus, Pascal, Dally, Heike, Hagemann, Christine, Diesing, Joanna ORCID: 0000-0001-5809-583X and Schonfelder, Tonio (2022). Incidence, prevalence, and comorbidities of juvenile idiopathic arthritis in Germany: a retrospective observational cohort health claims database study. Pediatr. Rheumatol., 20 (1). LONDON: BMC. ISSN 1546-0096

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Abstract

Background Juvenile idiopathic arthritis (JIA) describes heterogenous categories of chronic inflammatory rheumatic conditions of unknown origin in children and adolescents. Epidemiological data in the literature vary, depending on geographic location, ethnicity and the case definition used. We evaluated epidemiology, especially that of the categories defined by the International League of Associations for Rheumatology (ILAR). Methods Using data from two different longitudinal health claims databases (WIG2 and InGef) from January 1(st), 2013 to December 31(st), 2019, we looked at patients aged 2 to 15 years old with at least one main inpatient or two secondary inpatient/verified outpatient ICD-10 diagnoses in at least two different quarters within one calendar year. We calculated prevalence and incidence (per 100,000 patients) and extrapolated data to the entire German population, looking at differences in gender and age groups. Additionally, we collected data on other not necessary comorbidities in our JIA patient population. Results Of the 3-4 million patients in the databases (respectively) in 2018, we found a total of 546 (WIG2) and 849 (InGef) patients that met our JIA case definition, with an incidence of 34 (29-41) and 60 (53-67) and prevalence of 133 (122-145) and 168 (157-179). Both incidence and prevalence throughout the age range were mostly higher in females than males, however the difference between females and males increased with increasing age. Of the ILAR categories, oligoarthritis was the most prevalent (70 and 91 per 100,000), with about half of our JIA patients in this category, followed by undifferentiated arthritis (49 and 56 cases per 100,000) and rheumatoid factor negative (RF-) (31 and 39 per 100,000). Incidence in 2018 was the highest in these three categories. Atopic dermatitis, vasomotor and allergic rhinitis, and uveitis were the pre-defined comorbidities seen most often in both databases. Conclusion This study provides current incidence and prevalence JIA data in Germany, contributing to knowledge on burden of disease and tools for healthcare planning.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Horneff, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchert, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinrich, Ria UNSPECIFIED UNSPECIFIED UNSPECIFIED Kock, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Klaus, Pascal UNSPECIFIED UNSPECIFIED UNSPECIFIED Dally, Heike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagemann, Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Diesing, Joanna UNSPECIFIED orcid.org/0000-0001-5809-583X UNSPECIFIED Schonfelder, Tonio UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679770
DOI:	10.1186/s12969-022-00755-x
Journal or Publication Title:	Pediatr. Rheumatol.
Volume:	20
Number:	1
Date:	2022
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1546-0096
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RISK; CHILDREN; EPIDEMIOLOGY; VALIDITY; DISEASES Multiple languages Pediatrics; Rheumatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67977