Schmitz, Katrin ORCID: 0000-0003-3377-4232, Turnwald, Eva-Maria, Kretschmer, Tobias ORCID: 0000-0002-4202-0806, Janoschek, Ruth, Bae-Gartz, Inga ORCID: 0000-0002-4061-503X, Vossbrecher, Kathrin, Kammerer, Merlin D., Koeninger, Angela, Gellhaus, Alexandra ORCID: 0000-0001-9506-4581, Handwerk, Marion, Wohlfarth, Maria, Gruendemann, Dirk, Hucklenbruch-Rother, Eva, Doetsch, Joerg and Appel, Sarah ORCID: 0000-0003-0315-6513 (2022). Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice. Nutrients, 14 (11). BASEL: MDPI. ISSN 2072-6643

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Abstract

With the gaining prevalence of obesity, related risks during pregnancy are rising. Inflammation and oxidative stress are considered key mechanisms arising in white adipose tissue (WAT) sparking obesity-associated complications and diseases. The established anti-diabetic drug metformin reduces both on a systemic level, but only little is known about such effects on WAT. Because inhibiting these mechanisms in WAT might prevent obesity-related adverse effects, we investigated metformin treatment during pregnancy using a mouse model of diet-induced maternal obesity. After mating, obese mice were randomised to metformin administration. On gestational day G15.5, phenotypic data were collected and perigonadal WAT (pgWAT) morphology and proteome were examined. Metformin treatment reduced weight gain and visceral fat accumulation. We detected downregulation of perilipin-1 as a correlate and observed indications of recovering respiratory capacity and adipocyte metabolism under metformin treatment. By regulating four newly discovered potential adipokines (alpha-1 antitrypsin, Apoa4, Lrg1 and Selenbp1), metformin could mediate anti-diabetic, anti-inflammatory and oxidative stress-modulating effects on local and systemic levels. Our study provides an insight into obesity-specific proteome alterations and shows novel modulating effects of metformin in pgWAT of obese dams. Accordingly, metformin therapy appears suitable to prevent some of obesity's key mechanisms in WAT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schmitz, KatrinUNSPECIFIEDorcid.org/0000-0003-3377-4232UNSPECIFIED
Turnwald, Eva-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kretschmer, TobiasUNSPECIFIEDorcid.org/0000-0002-4202-0806UNSPECIFIED
Janoschek, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bae-Gartz, IngaUNSPECIFIEDorcid.org/0000-0002-4061-503XUNSPECIFIED
Vossbrecher, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kammerer, Merlin D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koeninger, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gellhaus, AlexandraUNSPECIFIEDorcid.org/0000-0001-9506-4581UNSPECIFIED
Handwerk, MarionUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wohlfarth, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gruendemann, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hucklenbruch-Rother, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doetsch, JoergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Appel, SarahUNSPECIFIEDorcid.org/0000-0003-0315-6513UNSPECIFIED
URN: urn:nbn:de:hbz:38-679809
DOI: 10.3390/nu14112288
Journal or Publication Title: Nutrients
Volume: 14
Number: 11
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6643
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BODY-MASS INDEX; BINDING PROTEIN-1 SELENBP1; MATERNAL OBESITY; MITOCHONDRIAL-FUNCTION; ENERGY-EXPENDITURE; OXIDATIVE STRESS; WEIGHT-GAIN; INSULIN; RISK; INFLAMMATIONMultiple languages
Nutrition & DieteticsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/67980

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