Universität zu Köln

Bedetti, Benedetta ORCID: 0000-0002-4362-1443, Schnorr, Philipp ORCID: 0000-0002-8853-9371, May, Sarah, Ruhlmann, Juergen, Ahmadzadehfar, Hojjat, Essler, Markus, Quaas, Alexander, Buettner, Reinhard, Schmidt, Joachim, Palmedo, Holger, Ko, Yon-Dschun and Wilhelm, Kai (2022). Multidisciplinary Postoperative Validation of F-18-FDG PET/CT Scan in Nodal Staging of Resected Non-Small Cell Lung Cancer. J. Clin. Med., 11 (23). BASEL: MDPI. ISSN 2077-0383

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Abstract

Background: The aim of this study was to examine the validity of PET/CT scans in the preoperative identification of lymph node metastases (LNM) and compare them with postoperative outcomes. Methods: In this retrospective study, we included 87 patients with a solitary lung nodule or biopsy-proven non-small cell lung cancer treated in our institution from 2009 to 2015. Patients were divided into two groups and four subgroups, depending on pre- and postoperative findings. Results: According to our analysis, PET/CT scan has a sensitivity of 50%, a specificity of 88.89%, a positive predictive value of 63.16%, and a negative predictive value of 82.35%. Among the patients, 13.8% were downstaged in PET-CT, while 8% were upstaged. In 78.2% of cases, the PET/CT evaluation was consistent with the histology. Metastases without extracapsular invasion were seldom recognized on PET/CT. Conclusions: This analysis showed the significance of extracapsular tumor invasion, which causes an inflammatory reaction, on LNM, which is probably responsible for preoperative false-positive findings. In conclusion, PET/CT scans are very effective in identifying patients without tumors. Furthermore, it is highly probable that patients with negative findings are free of disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bedetti, Benedetta UNSPECIFIED orcid.org/0000-0002-4362-1443 UNSPECIFIED Schnorr, Philipp UNSPECIFIED orcid.org/0000-0002-8853-9371 UNSPECIFIED May, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhlmann, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahmadzadehfar, Hojjat UNSPECIFIED UNSPECIFIED UNSPECIFIED Essler, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Buettner, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmidt, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Palmedo, Holger UNSPECIFIED UNSPECIFIED UNSPECIFIED Ko, Yon-Dschun UNSPECIFIED UNSPECIFIED UNSPECIFIED Wilhelm, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-679867
DOI:	10.3390/jcm11237215
Journal or Publication Title:	J. Clin. Med.
Volume:	11
Number:	23
Date:	2022
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language 8TH EDITION; FDG-PET/CT; MANAGEMENT; CT; DIAGNOSIS; IMPACT Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/67986