Universität zu Köln

Jonas, Jost B., Xu, Liang, Wei, Wen Bin, Jonas, Rahul A. and Wang, Ya Xing (2022). Progression and associated factors of lacquer cracks/patchy atrophies in high myopia: the Beijing Eye Study 2001-2011. Graefes Arch. Clin. Exp. Ophthalmol., 260 (10). S. 3221 - 3230. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

Purpose To assess the development and progression of lacquer cracks/patchy atrophies (LCs/PAs) in high myopia. Methods The case control study included highly myopic eyes (refractive error <= - 6.0 diopters), examined in the population-based Beijing Eye Study 2001/2011. Using fundus photographs taken in 2001 and 2011 and optical coherence tomographic images obtained in 2011, we assessed the incidence and enlargement of pre-existing LC/PAs. Results The study included 89 highly myopic eyes (age: 65.0 +/- 9.4 years). Newly developed or enlarged LC/PAs were detected in 17 (19.1%; 95% confidence interval (CI): 11.0, 27.0) eyes, with a new LC development without previous LCs, enlargement of a pre-existing LC, LC enlargement to a PA, development of a new PA without any previous LCs, and enlargement of a pre-existing PA detected in 3, 3, 5, 3, and 3 eyes, respectively. In 14 (82.4%; 95%CI: 62.3, 100) of the 17 eyes with LC/PA development or enlargement, the LC/PAs elongated perpendicularly to, and widened in, the direction of gamma zone enlargement. Higher prevalence of LC/PA enlargement was associated (multivariable analysis) with higher myopic maculopathy stage in 2001 (odds ratio (OR): 7.83; 95%CI: 2.65, 23.2; P < 0.001) and higher frequency of parapapillary delta zone enlargement (OR: 32.0; 95%CI: 3.07, 334; P < 0.001). Prevalence of LC/PA enlargement was lower than the prevalence of changes in other myopic maculopathy features (disc-fovea distance elongation: 71%; choroidal vessel shift: 55%; reduction in ophthalmoscopical disc size: 34%; ophthalmoscopic disc size enlargement: 25%). All eyes with LC/PA enlargement showed a pre-existing and enlarging gamma zone. Conclusions Development and enlargement of LC/PAs were associated with enlargement of parapapillary delta zone and often occurred in association with the direction of gamma zone enlargement.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jonas, Jost B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Xu, Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Wei, Wen Bin UNSPECIFIED UNSPECIFIED UNSPECIFIED Jonas, Rahul A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Ya Xing UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680175
DOI:	10.1007/s00417-022-05705-7
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	260
Number:	10
Page Range:	S. 3221 - 3230
Date:	2022
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AXIAL LENGTH; GAMMA ZONE; MACULOPATHY; POPULATION; PREVALENCE Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68017