ToVinh, Michael, Hoerr, Gregor, Dobrikova, Kristiyana, Gotter, Christina, Rommel, Clemens, Hoffmeister, Christoph, Raabe, Jan, Kaiser, Kim M., Finnemann, Claudia, Bischoff, Jenny ORCID: 0000-0002-7700-2915, Rieke, Gereon J., Wilhelm, Christoph ORCID: 0000-0002-9839-0291, Schmitt, Vanessa, Moehl, Christoph, Aghabeig, Mansoureh, Schwarze-Zander, Carolynne, Boesecke, Christoph, van Bremen, Kathrin, Wasmuth, Jan-Christian, Strassburg, Christian P., Rockstroh, Juergen K., Spengler, Ulrich, Kraemer, Benjamin and Nattermann, Jacob (2022). Mitochondrial Dysfunction Contributes to Impaired Cytokine Production of CD56(bright) Natural Killer Cells From Human Immunodeficiency Virus-Infected Individuals Under Effective Antiretroviral Therapy. J. Infect. Dis., 226 (5). S. 901 - 907. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6613

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Abstract

Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, we found HIV+ CD56(bright) NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with interferon gamma (IFN-gamma) production of NK cells. Finally, we demonstrated that stimulation of HIV+ NK cells with MitoTEMPO, a mitochondria-targeting antioxidant, significantly improved IFN-gamma production. We identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
ToVinh, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoerr, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobrikova, KristiyanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gotter, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rommel, ClemensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmeister, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raabe, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, Kim M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finnemann, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bischoff, JennyUNSPECIFIEDorcid.org/0000-0002-7700-2915UNSPECIFIED
Rieke, Gereon J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilhelm, ChristophUNSPECIFIEDorcid.org/0000-0002-9839-0291UNSPECIFIED
Schmitt, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moehl, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aghabeig, MansourehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwarze-Zander, CarolynneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boesecke, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Bremen, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wasmuth, Jan-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strassburg, Christian P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rockstroh, Juergen K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spengler, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kraemer, BenjaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nattermann, JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-680231
DOI: 10.1093/infdis/jiac103
Journal or Publication Title: J. Infect. Dis.
Volume: 226
Number: 5
Page Range: S. 901 - 907
Date: 2022
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6613
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Immunology; Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/68023

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