Universität zu Köln

Jirak, Peter, Mirna, Moritz, Rezar, Richard ORCID: 0000-0002-7118-501X, Motloch, Lukas J., Lichtenauer, Michael, Jordan, Jens, Binneboessel, Stephan, Tank, Jens, Limper, Ulrich and Jung, Christian ORCID: 0000-0001-8325-250X (2022). How spaceflight challenges human cardiovascular health. Eur. J. Prev. Cardiol., 29 (10). S. 1399 - 1412. OXFORD: OXFORD UNIV PRESS. ISSN 2047-4881

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Abstract

The harsh environmental conditions in space, particularly weightlessness and radiation exposure, can negatively affect cardiovascular function and structure. In the future, preventive cardiology will be crucial in enabling safe space travel. Indeed, future space missions destined to the Moon and from there to Mars will create new challenges to cardiovascular health while limiting medical management. Moreover, commercial spaceflight evolves rapidly such that older persons with cardiovascular risk factors will be exposed to space conditions. This review provides an overview on studies conducted in space and terrestrial models, particularly head-down bedrest studies. These studies showed that weightlessness elicits a fluid shift towards the head, which likely predisposes to the spaceflight-associated neuro-ocular syndrome, neck vein thrombosis, and orthostatic intolerance after return to Earth. Moreover, cardiovascular unloading produces cardiopulmonary deconditioning, which may be associated with cardiac atrophy. In addition to limiting physical performance, the mechanism further worsens orthostatic tolerance after return to Earth. Finally, space conditions may directly affect vascular health; however, the clinical relevance of these findings in terms of morbidity and mortality is unknown. Targeted preventive measures, which are referred to as countermeasures in aerospace medicine, and technologies to identify vascular risks early on will be required to maintain cardiovascular performance and health during future space missions.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Jirak, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Mirna, Moritz UNSPECIFIED UNSPECIFIED UNSPECIFIED Rezar, Richard UNSPECIFIED orcid.org/0000-0002-7118-501X UNSPECIFIED Motloch, Lukas J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtenauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Binneboessel, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Tank, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Limper, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, Christian UNSPECIFIED orcid.org/0000-0001-8325-250X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-680250
DOI:	10.1093/eurjpc/zwac029
Journal or Publication Title:	Eur. J. Prev. Cardiol.
Volume:	29
Number:	10
Page Range:	S. 1399 - 1412
Date:	2022
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	2047-4881
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-DURATION SPACEFLIGHT; ACUTE SLEEP-DEPRIVATION; FLUID SHIFTS; HEART-RATE; ARTERIAL-PRESSURE; VENOUS-PRESSURE; CARDIAC ATROPHY; QTC INTERVALS; OXYGEN-UPTAKE; MICROGRAVITY Multiple languages Cardiac & Cardiovascular Systems Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/68025